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乳糖醇通过调节血清素、短链脂肪酸和肠道微生物群减轻洛哌丁胺诱导的Sprague Dawley大鼠便秘。

Lactitol Alleviates Loperamide-Induced Constipation in Sprague Dawley Rats by Regulating Serotonin, Short-Chain Fatty Acids, and Gut Microbiota.

作者信息

Jang Joo Hyun, Kim Sang Min, Suh Hyung Joo, Gim Minchul, Shin Hoyeon, Jang Hyunsook, Choi Hyeon-Son, Han Sung Hee, Chang Yeok Boo

机构信息

Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, Republic of Korea.

Transdisciplinary Major in Learning Health Systems, Department of Healthcare Sciences, Graduate School, Korea University, Seoul 02841, Republic of Korea.

出版信息

Foods. 2024 Jul 3;13(13):2128. doi: 10.3390/foods13132128.

DOI:10.3390/foods13132128
PMID:38998634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11240941/
Abstract

The objective of this study was to examine the impact of lactitol on constipation caused by loperamide in Sprague Dawley rats, with a particular emphasis on its underlying mechanisms and potential health advantages. The lactitol effectively improved fecal parameters, intestinal tissue structure, and the expression of constipation-related gene expression and proteins. Lactitol alleviated fecal weight and water content altered by loperamide and enhanced gastrointestinal transit. The administration also restored mucosal and muscular layer thickness. Mechanistically, lactitol upregulated the mRNA expression and/or protein levels of mucins (MUC2 and MUC4), occludin, claudin-1, and zonula occludens, indicating improved intestinal barrier function. Lactitol positively regulated the composition of cecal microbiota, leading to an increased relative abundance of , , and . Conversely, lactitol decreased the relative abundance of , , , , and . This study demonstrated the potential of lactitol to relieve constipation by modulating the gut microbiota. These findings suggest that lactitol is an alternative to traditional laxatives and has potential as a health-promoting food sweetener.

摘要

本研究的目的是研究乳糖醇对斯普拉格-道利大鼠中由洛哌丁胺引起的便秘的影响，特别关注其潜在机制和潜在的健康益处。乳糖醇有效改善了粪便参数、肠道组织结构以及便秘相关基因表达和蛋白质的表达。乳糖醇减轻了洛哌丁胺改变的粪便重量和含水量，并增强了胃肠运输。给药还恢复了黏膜和肌层厚度。从机制上讲，乳糖醇上调了粘蛋白（MUC2和MUC4）、闭合蛋白、紧密连接蛋白-1和闭合小带的mRNA表达和/或蛋白质水平，表明肠道屏障功能得到改善。乳糖醇对盲肠微生物群的组成有正向调节作用，导致[具体微生物名称1]、[具体微生物名称2]和[具体微生物名称3]的相对丰度增加。相反，乳糖醇降低了[具体微生物名称4]、[具体微生物名称5]、[具体微生物名称6]、[具体微生物名称7]和[具体微生物名称8]的相对丰度。本研究证明了乳糖醇通过调节肠道微生物群缓解便秘的潜力。这些发现表明，乳糖醇是传统泻药的替代品，具有作为促进健康的食品甜味剂的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/cb6dbb319a85/foods-13-02128-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/453f34de9f80/foods-13-02128-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/9066ddfd354f/foods-13-02128-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/c894bd6909fd/foods-13-02128-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/12b8b0795d03/foods-13-02128-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/e6254687fe0f/foods-13-02128-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/ded043e22fff/foods-13-02128-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/5389c0a7c359/foods-13-02128-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/26b8ad5eeeea/foods-13-02128-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/a213cd795805/foods-13-02128-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/29b26f8c50ec/foods-13-02128-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/cb6dbb319a85/foods-13-02128-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/453f34de9f80/foods-13-02128-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/9066ddfd354f/foods-13-02128-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/c894bd6909fd/foods-13-02128-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/12b8b0795d03/foods-13-02128-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/e6254687fe0f/foods-13-02128-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/ded043e22fff/foods-13-02128-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/5389c0a7c359/foods-13-02128-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/26b8ad5eeeea/foods-13-02128-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/a213cd795805/foods-13-02128-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/29b26f8c50ec/foods-13-02128-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2046/11240941/cb6dbb319a85/foods-13-02128-g011.jpg

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