Jang Ye-Ji, Moon Jin Seok, Kim Ji Eun, Kim Dayoung, Choi Han Sol, Oh Ikhoon
Research Laboratories at ILDONG Pharmaceutical Co., Ltd., Hwaseong 18449, Korea.
Food Sci Anim Resour. 2024 Jan;44(1):119-131. doi: 10.5851/kosfa.2023.e61. Epub 2024 Jan 1.
BIOVITA 3 bacterial species (BIOVITA 3), a probiotic blend powder containing IDCC 1301, IDCC 1201 and IDCC 1101, has been used as a food ingredient for gut health. However, its efficacy in improving constipation has not been reported. Therefore, we aimed to investigate the functional effects of oral administration of BIOVITA 3 as well as its component strains alone (at 1.0×10 CFU/day) in Sprague-Dawley (SD) rats with loperamide-induced constipation. The study included fecal analysis, gastrointestinal transit ratio, histopathological analysis, short chain fatty acids (SCFAs), and metagenome analysis. As results, the BIOVITA 3 group showed significant improvements in fecal number, water content, gastrointestinal transit ratio, and thickening of the mucosal layer. In the SCFAs analysis, all probiotic-treated groups showed an increase in total SCFAs compared to the loperamide-constipated group. Changes in microbial abundance and the diversity index of three groups (normal, constipated, and BIOVITA 3) were also defined. Of these, the BIOVITA 3 showed a significant improvement in loperamide-constipated SD-rats. This study suggests the possibility that BIOVITA 3 can be applied as an ingredient in functional foods to relieve constipation.
BIOVITA 3 种细菌（BIOVITA 3）是一种含有IDCC 1301、IDCC 1201 和 IDCC 1101 的益生菌混合粉末，已被用作促进肠道健康的食品成分。然而，其改善便秘的功效尚未见报道。因此，我们旨在研究口服BIOVITA 3 及其单独的成分菌株（每天1.0×10 CFU）对洛哌丁胺诱导便秘的Sprague-Dawley（SD）大鼠的功能作用。该研究包括粪便分析、胃肠转运率、组织病理学分析、短链脂肪酸（SCFAs）和宏基因组分析。结果显示，BIOVITA 3 组在粪便数量、水分含量、胃肠转运率和黏膜层增厚方面有显著改善。在短链脂肪酸分析中，与洛哌丁胺致便秘组相比，所有益生菌治疗组的总短链脂肪酸均有所增加。还确定了三组（正常、便秘和BIOVITA 3）微生物丰度和多样性指数的变化。其中，BIOVITA 3 对洛哌丁胺致便秘的SD大鼠有显著改善作用。这项研究表明，BIOVITA 3 有可能作为功能性食品的成分用于缓解便秘。
