评论赖等人：二肽基肽酶 4 刺激诱导脂肪基质细胞的脂肪生成相关基因表达。2023 年，16101 期。
Comment on Lai et al. Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells. 2023, , 16101.
机构信息
Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain.
出版信息
Int J Mol Sci. 2024 Jun 28;25(13):7093. doi: 10.3390/ijms25137093.
Adiponectin is a circulating hormone secreted by adipose tissue that exerts, unlike other adipokines such as leptin, anti-inflammatory, anti-atherosclerotic and other protective effects on health. Adiponectin receptor agonists are being tested in clinical trials and are expected to show benefits in many diseases. In a recent article, LW Chen's group used monocyte chemoattractant protein-1 (MCP-1/CCL2) to improve plasma levels of adiponectin, suggesting the involvement of dipeptidyl peptidase 4 (DPP4/CD26) in the mechanism. Here, we discuss the significance of the role of DPP4, favoring the increase in DPP4-positive interstitial progenitor cells, a finding that fits with the greater stemness and persistence of other DPP4/CD26-positive cells.
脂联素是一种由脂肪组织分泌的循环激素，与瘦素等其他脂肪细胞因子不同，它对健康具有抗炎、抗动脉粥样硬化等保护作用。脂联素受体激动剂正在临床试验中进行测试，预计将在许多疾病中显示出益处。在最近的一篇文章中，LW Chen 的研究小组使用单核细胞趋化蛋白 1（MCP-1/CCL2）来提高血浆脂联素水平，提示二肽基肽酶 4（DPP4/CD26）参与了这一机制。在这里，我们讨论了 DPP4 作用的意义，有利于增加 DPP4 阳性间质祖细胞，这一发现与其他 DPP4/CD26 阳性细胞的更大的干性和持久性相符。
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