Department of Pharmacology, School of Medicine, Aichi Medical University, Nagakute 480-1195, Aichi, Japan.
Int J Mol Sci. 2024 Jun 28;25(13):7144. doi: 10.3390/ijms25137144.
In recent years, there has been a growing realization of intricate interactions between the nervous and immune systems, characterized by shared humoral factors and receptors. This interplay forms the basis of the neuroimmune system, the understanding of which will provide insights into the pathogenesis of neurological diseases, in which the involvement of the immune system has been overlooked. Kynurenine and its derivatives derived from tryptophan have long been implicated in the pathogenesis of various neurological diseases. Recent studies have revealed their close association not only with neurological disorders but also with sepsis-related deaths. This review provides an overview of the biochemistry of kynurenine and its derivatives, followed by a discussion of their role via the modulation of the neuroimmune system in various diseases.
近年来，人们越来越认识到神经系统和免疫系统之间存在着错综复杂的相互作用，其特征是存在共同的体液因子和受体。这种相互作用构成了神经免疫系统的基础，对其的理解将为深入了解神经系统疾病的发病机制提供新的思路，而这些疾病的发病机制中免疫系统的参与一直被忽视。色氨酸衍生的犬尿氨酸及其衍生物长期以来一直被认为与各种神经疾病的发病机制有关。最近的研究表明，它们不仅与神经紊乱有关，而且与与脓毒症相关的死亡有关。本综述概述了犬尿氨酸及其衍生物的生物化学特性，然后讨论了它们通过调节神经免疫系统在各种疾病中的作用。
