Park Meerim, Lee Dong-Eun, Hong Yuna, Suh Jin Kyung, Lee Jun Ah, Kim Myungshin, Park Hyeon Jin
Department of Pediatrics, Center for Pediatric Cancer, National Cancer Center, Goyang 10408, Republic of Korea.
Biostatic Collaboration Team, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea.
Cancers (Basel). 2024 Jun 26;16(13):2344. doi: 10.3390/cancers16132344.
We examined the leukocyte relative telomere length (RTL) in Korean adolescent and young adult (AYA) survivors of childhood cancer and evaluated the association of leukocyte RTL with multiple factors, including malignancy type, cancer treatment, age, and chronic health conditions (CHCs). Eighty-eight AYA survivors of childhood cancer with a median follow-up period of 73 months were recruited. RTL in pediatric cancer survivors was not significantly shorter than the predicted value for age-matched references. Neither age at diagnosis nor duration of therapy influenced the RTL. Among the 43 patients with hematologic malignancies, those who underwent allogeneic hematopoietic stem cell transplantation (HSCT) showed a significant shortening of the RTL compared with those who did not ( = 0.039). Among the 15 patients who underwent allogeneic HSCT, those who developed acute graft-versus-host disease (GVHD) of grade II or higher had significantly shorter RTL than those who did not ( = 0.012). Patients with grade II CHCs had significantly shorter RTL than those without CHCs or with grade I CHCs ( = 0.001). Survivors with ≥2 CHCs also exhibited shorter RTL ( = 0.027). Overall, pediatric cancer survivors had similar telomere lengths compared to age-matched references. HSCT recipients and patients with severe or multiple CHCs had shorter telomeres. GVHD augmented telomere attrition in HSCT recipients.
我们检测了韩国儿童癌症青少年及年轻成人（AYA）幸存者的白细胞相对端粒长度（RTL），并评估了白细胞RTL与多种因素的关联，这些因素包括恶性肿瘤类型、癌症治疗、年龄和慢性健康状况（CHC）。招募了88名儿童癌症AYA幸存者，中位随访期为73个月。儿科癌症幸存者的RTL并不显著短于年龄匹配对照的预测值。诊断时的年龄和治疗持续时间均未影响RTL。在43例血液系统恶性肿瘤患者中，接受异基因造血干细胞移植（HSCT）的患者与未接受移植的患者相比，RTL显著缩短（P = 0.039）。在15例接受异基因HSCT的患者中，发生II级或更高等级急性移植物抗宿主病（GVHD）的患者的RTL显著短于未发生的患者（P = 0.012）。患有II级CHC的患者的RTL显著短于无CHC或患有I级CHC的患者（P = 0.001）。患有≥2种CHC的幸存者的RTL也较短（P = 0.027）。总体而言，儿科癌症幸存者的端粒长度与年龄匹配对照相似。HSCT受者和患有严重或多种CHC的患者的端粒较短。GVHD加剧了HSCT受者的端粒损耗。
