神经内分泌肿瘤患者生存情况的性别差异：两个国家数据库的比较研究
Sex Differences in the Survival of Patients with Neuroendocrine Neoplasms: A Comparative Study of Two National Databases.
作者信息
Mortagy Mohamed, El Asmar Marie Line, Chandrakumaran Kandiah, Ramage John
机构信息
Hampshire Hospitals NHS Foundation Trust, Winchester SO22 5DG, UK.
Internal Medicine Department, St. George University School of Medicine, West Indies, Grenada.
出版信息
Cancers (Basel). 2024 Jun 28;16(13):2376. doi: 10.3390/cancers16132376.
BACKGROUND
Neuroendocrine neoplasms (NENs) are increasing in incidence globally. Previous analysis of the UK cancer database (National Cancer Registration and Analysis Service (NCRAS)) showed a notable female survival advantage in most tumour sites. This study aims to compare NCRAS to the Surveillance, Epidemiology, and End Results Program (SEER) to validate these results using the same statistical methods.
METHODS
A total of 14,834 and 108,399 patients with NENs were extracted from NCRAS and SEER, respectively. Sixty-months survival for both males and females for each anatomical site of NENs were calculated using restricted mean survival time (RMST) and Kaplan-Meier Survival estimates. The sixty-month RMST female survival advantage (FSA) was calculated.
RESULTS
FSA was similar in NCRAS and SEER. The highest FSA occurred in lung and stomach NENs.
CONCLUSIONS
The data from SEER confirm the findings published by NCRAS. Female survival advantage remains unexplained.
背景
神经内分泌肿瘤（NENs）在全球范围内的发病率正在上升。先前对英国癌症数据库（国家癌症登记与分析服务局（NCRAS））的分析显示，在大多数肿瘤部位，女性具有显著的生存优势。本研究旨在将NCRAS与监测、流行病学和最终结果计划（SEER）进行比较，以使用相同的统计方法验证这些结果。
方法
分别从NCRAS和SEER中提取了14834例和108399例NENs患者。使用受限平均生存时间（RMST）和Kaplan-Meier生存估计法计算了NENs各解剖部位男性和女性的60个月生存率。计算了60个月RMST女性生存优势（FSA）。
结果
NCRAS和SEER中的FSA相似。最高的FSA出现在肺和胃NENs中。
结论
SEER的数据证实了NCRAS发表的研究结果。女性生存优势的原因仍不明。
Zotero 插件