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来自白血病血样的白血病源树突状细胞在缺氧与常氧条件下诱导的抗白血病效应相当。

Anti-Leukemic Effects Induced by Dendritic Cells of Leukemic Origin from Leukemic Blood Samples Are Comparable under Hypoxic vs. Normoxic Conditions.

作者信息

Doraneh-Gard Fatemeh, Amberger Daniel Christoph, Amend Carina, Weinmann Melanie, Schwepcke Christoph, Klauer Lara, Schutti Olga, Hosseini Hedayatollah, Krämer Doris, Rank Andreas, Schmid Christoph, Schmetzer Helga Maria

机构信息

Medical Department III, Working-group Immune-Modulation, Klinikum Großhadern, Ludwig-Maximilians-University, 81377 Munich, Germany.

Bavarian Cancer Research Center (BZKF), 86156 Augsburg, Germany.

出版信息

Cancers (Basel). 2024 Jun 28;16(13):2383. doi: 10.3390/cancers16132383.

DOI:10.3390/cancers16132383
PMID:39001445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11240788/
Abstract

Hypoxia can modulate the immune system by affecting the function and activity of immune cells, potentially leading to altered immune responses. This study investigated the generation of leukemia-derived dendritic cells (DC from leukemic blasts and their impact on immune cell activation under hypoxic (5-10% O) compared to normoxic (21% O) conditions using various immunomodulatory Kits. The results revealed that DC/DC-generation was similar under hypoxic and normoxic conditions, with no significant differences observed in frequencies of generated DC/DC. Furthermore, the study showed that the activation of immune cells and their anti-leukemic activity improved when T cell-enriched immunoreactive cells were co-cultured with DC/DC which were generated with Kit I and M compared to the control after mixed lymphocyte cultures. The anti-leukemic activity was improved under hypoxic compared to normoxic conditions after MLC. These findings suggest that DC/DC-cultures of leukemic whole blood with Kits under hypoxic conditions yield comparable frequencies of DC/DC and can even increase the anti-leukemic activity compared to normoxic conditions. Overall, this research highlights the potential of utilizing DC/DC (potentially induced in vivo with Kits) as a promising approach to enhance immune response in patients with acute myeloid leukemia.

摘要

缺氧可通过影响免疫细胞的功能和活性来调节免疫系统，这可能会导致免疫反应发生改变。本研究使用各种免疫调节试剂盒，调查了白血病来源的树突状细胞（由白血病原始细胞生成的DC）在低氧（5%-10% O₂）与常氧（21% O₂）条件下的生成情况及其对免疫细胞激活的影响。结果显示，低氧和常氧条件下DC/DC的生成情况相似，生成的DC/DC频率无显著差异。此外，研究表明，在混合淋巴细胞培养后，与对照组相比，当富含T细胞的免疫反应性细胞与用试剂盒I和M生成的DC/DC共培养时，免疫细胞的激活及其抗白血病活性得到改善。混合淋巴细胞培养后，与常氧条件相比，低氧条件下抗白血病活性有所提高。这些发现表明，在低氧条件下用试剂盒对白血病全血进行DC/DC培养可产生相当频率的DC/DC，与常氧条件相比甚至可增强抗白血病活性。总体而言，本研究突出了利用DC/DC（可能用试剂盒在体内诱导生成）作为增强急性髓系白血病患者免疫反应的一种有前景方法的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/c80d88a22402/cancers-16-02383-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/972333a6ef2d/cancers-16-02383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/71830899f055/cancers-16-02383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/0c9575fbfde1/cancers-16-02383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/a4a331981e9f/cancers-16-02383-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/545863a7038e/cancers-16-02383-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/c80d88a22402/cancers-16-02383-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/972333a6ef2d/cancers-16-02383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/71830899f055/cancers-16-02383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/0c9575fbfde1/cancers-16-02383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/a4a331981e9f/cancers-16-02383-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/545863a7038e/cancers-16-02383-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ffea/11240788/c80d88a22402/cancers-16-02383-g006.jpg

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