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颈内动脉支架在颅底副神经节瘤治疗中的作用

The Role of Internal Carotid Artery Stent in the Management of Skull Base Paragangliomas.

作者信息

Di Micco Riccardo, Salcher Rolf Benedikt, Götz Friedrich, Abu Fares Omar, Lenarz Thomas

机构信息

Department of Otolaryngology, Hannover Medical School, 30625 Hannover, Germany.

Department of Neuroradiology, Hannover Medical School, 30625 Hannover, Germany.

出版信息

Cancers (Basel). 2024 Jul 5;16(13):2461. doi: 10.3390/cancers16132461.

Abstract

After two decades from its introduction in the lateral skull base paraganglioma surgery, the indications and results of preoperative internal carotid artery stenting should be critically assessed. Monocentric retrospective study on 26 patients affected by head and neck paragangliomas (19 tympanojugular paragangliomas, 4 carotid body paragangliomas, 3 vagal paragangliomas) preoperatively treated with internal carotid artery stents between 2008 and 2023. The preoperative findings, the intraoperative complications and the final surgical results were analyzed. The stent complication rate was less than 3.1%. Self-expanding highly flexible intracranial nitinol stents were applied. In all cases, it was possible to completely mobilize the internal carotid artery and perform a vascular dissection of the tumor. Gross total tumor resection was possible in 85% of cases. The median follow up was 7.83 y (SD +/- 3.93 y). No local recurrence was observed. The preoperative vascular stent facilitates tumor dissection from the internal carotid artery without risk of vascular damage, helping the surgeon to achieve surgical radicality. The vascular stent is indicated in the case of revision surgeries, circumferential involvement of the vessel and in cases with non-insufficient intracerebral crossflow. Procedural complications, temporary antiplatelet therapy and delay of surgery are the limitations of the procedure.

摘要

自颅底外侧副神经节瘤手术引入术前颈内动脉支架置入术二十年来,应对其适应症和结果进行严格评估。对2008年至2023年间接受颈内动脉支架置入术术前治疗的26例头颈部副神经节瘤患者(19例鼓室颈静脉副神经节瘤、4例颈动脉体副神经节瘤、3例迷走神经副神经节瘤)进行单中心回顾性研究。分析术前检查结果、术中并发症及最终手术结果。支架并发症发生率低于3.1%。应用了自膨式高柔韧性颅内镍钛合金支架。在所有病例中,均能够完全游离颈内动脉并对肿瘤进行血管分离。85%的病例实现了肿瘤全切。中位随访时间为7.83年(标准差±3.93年)。未观察到局部复发。术前血管支架有助于从颈内动脉分离肿瘤,且无血管损伤风险,有助于外科医生实现手术根治性。血管支架适用于翻修手术、血管周向受累及脑内交叉血流不充分的病例。手术并发症、临时抗血小板治疗及手术延迟是该手术的局限性。

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