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少突胶质细胞瘤:撒哈拉以南非洲地区的神经学视角

Oligodendroglioma: a neurological perspective in Sub-saharan Africa.

作者信息

James Emmanuel, Okon Inibehe Ime, Akpan Usoro, Abigail Onoja

机构信息

Department of Medicine and Surgery, University of Benin, Benin City, Edo state, Nigeria.

Department of Neurosurgery, Dell Medical School, University of Texas, Austin, TX, USA.

出版信息

Neurosurg Rev. 2024 Jul 13;47(1):321. doi: 10.1007/s10143-024-02579-7.

DOI:10.1007/s10143-024-02579-7
PMID:39002027
Abstract

Gliomas are a kind of brain cancer that develops from glial cells. Glial cells provide nourishment and energy to nerve cells, and they also preserve the blood-brain barrier. A primary cancer of the central nervous system (CNS) is oligodendroglioma. This suggests that it originates in the brain or spinal cord. While oligodendrogliomas can strike anyone at any age, the age range of 35 to 44 is when they most commonly occur. Oligodendrogliomas are rare in young people and more common in men than women. Based on anecdotal data, patients with oligodendroglioma may present management challenges in Africa. There are delays in diagnosis and referrals due to the scarcity of neuroimaging facilities. A wide range of strategies have been put forth to improve pathology services in low- and middle-income nations. Adequate mentorship, short-term visitor programs, overcoming supply chain constraints, establishing training standards, and establishing the role of pathologists in cancer screening and early diagnosis have all been proposed as solutions to this problem. To sum up, oligodendroglioma is one of the low-grade gliomas this study looked at. Brain cancer is a serious public health concern in Africa. Improved options for screening and therapy are required to better address this problem.

摘要

胶质瘤是一种起源于神经胶质细胞的脑癌。神经胶质细胞为神经细胞提供营养和能量,还维持血脑屏障。少突胶质细胞瘤是中枢神经系统的原发性癌症。这表明它起源于脑或脊髓。虽然少突胶质细胞瘤可在任何年龄侵袭任何人,但最常发生在35至44岁这个年龄段。少突胶质细胞瘤在年轻人中罕见,男性比女性更常见。根据传闻数据,少突胶质细胞瘤患者在非洲可能带来管理挑战。由于神经影像设施匮乏,存在诊断和转诊延迟的情况。为改善低收入和中等收入国家的病理学服务,已提出了一系列策略。充分的指导、短期访问者计划、克服供应链限制、建立培训标准以及确立病理学家在癌症筛查和早期诊断中的作用,都被提议作为解决这一问题的办法。总之,少突胶质细胞瘤是本研究关注的低级别胶质瘤之一。脑癌是非洲严重的公共卫生问题。需要改进筛查和治疗选择,以更好地应对这一问题。

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World Neurosurg. 2024 Jun;186:269. doi: 10.1016/j.wneu.2024.03.140.
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Recurrent artery of Heubner aneurysms in focus: insights into occurrence and current treatment paradigms.聚焦 Heubner 动脉瘤的反复性动脉:对发生机制和当前治疗模式的深入了解。
Neurochirurgie. 2024 Sep;70(5):101572. doi: 10.1016/j.neuchi.2024.101572. Epub 2024 May 24.
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Epidemiology and etiology of brain cancer in Africa: A systematic review.
非洲脑癌的流行病学和病因学:系统评价。
Brain Behav. 2023 Sep;13(9):e3112. doi: 10.1002/brb3.3112. Epub 2023 Jun 14.
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Management and Outcomes of Low-Grade Gliomas in Africa: A Scoping Review Protocol.非洲低级别胶质瘤的管理与治疗结果:一项范围综述方案
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Barriers to Management of Nontraumatic Neurosurgical Diseases at 2 Cameroonian Neurosurgical Centers: Cross-Sectional Study.喀麦隆 2 家神经外科中心非创伤性神经外科学疾病管理障碍:横断面研究。
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The Challenges of Management of High-grade Gliomas in Nigeria.尼日利亚高级别胶质瘤的管理挑战
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