Pérez-Cruz Elizabeth, Howlet-Caballero Luis Carlos, Villanueva Xicoténcatl Jiménez
Department Metabolic Unit and Nutritional Support, Hospital Juárez de México, Av. Instituto Politécnico Nacional Núm. 5160, Col. Magdalena de las Salinas, C.P. 07760, Del Gustavo A. Madero, Mexico City, México.
Obesity Clinic, Hospital Juárez de México, Mexico City, México.
Clin Transl Oncol. 2025 Feb;27(2):687-692. doi: 10.1007/s12094-024-03575-5. Epub 2024 Jul 13.
To determinate the association between of albumin, neutrophil-lymphocyte ratio and lymphocytes (NLR) with clinical stage in cervical cancers.
Design a retrospective cross-sectional study of consecutive subjects diagnosed with cervical cancer for the first time. The Bethesda system was used for histological diagnosis and the subjects were stratified with the FIGO system, considering stages IA to IIB as localized; while, IIIA and IVB as advanced stages. Albumin, NLR and lymphocytes were evaluated as inflammatory biomarkers and the cut-off points generated by the ROC curves were albumin < 3 mg/dL, NLR ≥ 2.0 and lymphocytes < 1.2 10/ul. The association was calculated by Odds Ratios (OR) with 95% confidence intervals.
A total of 152 patients were analyzed, with mean age of 49.3 ± 14.0 years. Epidermoid cancer was the most frequent in 70.6% and 51.3% were classified as advanced clinical stages. A bivariate analysis showed significant relationships between advanced clinical stages and albumin < 3 mg/dL with OR 5.72 (CI95% 2.62-12.4; p < 0.001); for NLR ≥ 2.0 an OR 2.53 (CI95% 1.34-4.89; p = 0.005) and for lymphocytes < 1.2 10/ul of OR 3.39 (CI95% = 1.73-6.65; p < 0.001).
Albumin levels < 3 mg/dL, NLR ≥ 2.0 and lymphocytes < 1.2 10/ul, were associated with advanced stages in subjects with cervical cancer.
确定白蛋白、中性粒细胞与淋巴细胞比值（NLR）和淋巴细胞与宫颈癌临床分期之间的关联。
设计一项针对首次诊断为宫颈癌的连续受试者的回顾性横断面研究。采用贝塞斯达系统进行组织学诊断，并根据国际妇产科联盟（FIGO）系统对受试者进行分层，将IA期至IIB期视为局部病变；而IIIA期和IVB期为晚期。将白蛋白、NLR和淋巴细胞作为炎症生物标志物进行评估，通过ROC曲线得出的截断点为白蛋白<3mg/dL、NLR≥2.0和淋巴细胞<1.2×10⁹/μL。通过比值比（OR）及95%置信区间计算关联。
共分析了152例患者，平均年龄为49.3±14.0岁。表皮样癌最为常见，占70.6%，51.3%被归类为晚期临床分期。双变量分析显示，晚期临床分期与白蛋白<3mg/dL之间存在显著关联，OR为5.72（95%CI 2.62 - 12.4；p<0.001）；NLR≥2.0时，OR为2.53（95%CI 1.34 - 4.89；p = 0.005）；淋巴细胞<1.2×10⁹/μL时，OR为3.39（95%CI = 1.73 - 6.65；p<0.001）。
白蛋白水平<3mg/dL、NLR≥2.0和淋巴细胞<1.2×10⁹/μL与宫颈癌患者的晚期分期相关。
