Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa, Chiba, 272-8513, Japan.
Shimazaki Eye Clinic, Tokyo, Japan.
Jpn J Ophthalmol. 2024 Sep;68(5):472-481. doi: 10.1007/s10384-024-01079-x. Epub 2024 Jul 13.
To assess the effects of 1% azithromycin ophthalmic solution (AZM) in patients with bacterial blepharitis accompanied by meibomian gland dysfunction (MGD).
A multicenter, single arm, prospective interventional study.
AZM was administered to the affected eyes twice daily for the first 2 days and once daily for the subsequent 12 days. Lid margin hyperaemia/redness, collarette at the root of the eyelashes, conjunctival hyperaemia, foreign body sensation, and epiphora were assessed on Days 1, 14, and 28. The Dry Eye-related Quality of Life Score (DEQS) and objectives related to MGD, including lid vascularity, lid margin irregularity, foaming, lid plugging, keratoconjunctival disorders, Marx line, meibum grade, and tear breakup time, were also assessed. Bacterial culture of the conjunctival sac and meibum was performed on Days 1 and 14.
Twenty-four eyes of 24 patients (10 men/14 women, mean age 72.3 ± 13.2) were included. On Days 14 and 28, the total score, lid vascularity, lid plugging, and meibum grade showed significant improvement (p < 0.05). On Day 1, 71 strains were isolated from 22 of the 24 eyes (91.7%). Cutibacterium acnes, Corynebacterium spp., and Staphylococci were detected at high frequencies. The overall disappearance rates of the bacteria in the conjunctival sac and meibum at the end of treatment were 65.7% and 58.3%, respectively. No serious ocular or systemic adverse events were observed.
Fourteen-day treatment with AZM was effective in patients with blepharitis accompanied by MGD, and the efficacy of AZM persisted for a period after the treatment.
评估 1%阿奇霉素滴眼液（AZM）在伴有睑板腺功能障碍（MGD）的细菌性睑缘炎患者中的疗效。
多中心、单臂、前瞻性干预研究。
在最初的 2 天，每天滴患眼 2 次，之后的 12 天每天滴患眼 1 次。在第 1、14 和 28 天评估眼睑缘充血/发红、睫毛根部的睫毛圈、结膜充血、异物感和溢泪。还评估了干眼相关生活质量评分（DEQS）和与 MGD 相关的指标，包括眼睑血管化、眼睑缘不规则、泡沫状、眼睑阻塞、角结膜疾病、Marx 线、睑脂分级和泪膜破裂时间。在第 1 和第 14 天对结膜囊和睑脂进行了细菌培养。
24 例患者（10 例男性/14 例女性，平均年龄 72.3±13.2 岁）的 24 只眼纳入研究。在第 14 天和第 28 天，总评分、眼睑血管化、眼睑阻塞和睑脂分级均有显著改善（p<0.05）。在第 1 天，从 24 只眼中的 22 只（91.7%）分离出 71 株菌。高度检测到痤疮丙酸杆菌、棒状杆菌和葡萄球菌。治疗结束时，结膜囊和睑脂中的细菌总体消失率分别为 65.7%和 58.3%。未观察到严重的眼部或全身不良事件。
14 天 AZM 治疗对伴有 MGD 的睑缘炎患者有效，并且 AZM 的疗效在治疗结束后仍持续一段时间。
