Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki 00790, Finland.
Neuroscience Center, HiLIFE, University of Helsinki, Helsinki 00290, Finland.
Eur J Cell Biol. 2024 Sep;103(3):151441. doi: 10.1016/j.ejcb.2024.151441. Epub 2024 Jul 6.
Integrins are heterodimeric membrane proteins expressed on the surface of most cells. They mediate adhesion and signaling processes relevant for a wealth of physiological processes, including nervous system development and function. Interestingly, integrins are also recognized therapeutic targets for inflammatory diseases, such as multiple sclerosis. Here, we discuss the role of integrins in brain development and function, as well as in neurodegenerative diseases affecting the brain (Alzheimer's disease, multiple sclerosis, stroke). Furthermore, we discuss therapeutic targeting of these adhesion receptors in inflammatory diseases of the brain.
整合素是一种异二聚体膜蛋白，表达于大多数细胞的表面。它们介导与多种生理过程相关的黏附和信号转导，包括神经系统的发育和功能。有趣的是，整合素也是炎症性疾病（如多发性硬化症）的治疗靶点。在这里，我们讨论了整合素在大脑发育和功能中的作用，以及在影响大脑的神经退行性疾病（阿尔茨海默病、多发性硬化症、中风）中的作用。此外，我们还讨论了这些黏附受体在大脑炎症性疾病中的治疗靶向作用。
