Center of Experimental and Innovative Medicine, University Centre of Veterinary Medicine JU-UA, University of Agriculture in Krakow, Redzina 1C, Krakow 30-248, Poland.
Center of Experimental and Innovative Medicine, University Centre of Veterinary Medicine JU-UA, University of Agriculture in Krakow, Redzina 1C, Krakow 30-248, Poland.
Vet Immunol Immunopathol. 2024 Aug;274:110804. doi: 10.1016/j.vetimm.2024.110804. Epub 2024 Jul 8.
Sepsis is still one of the most common causes of death of animals and humans. It is marked by an aberrant immune response to infection, resulting in extensive inflammation, organ dysfunction, and, in severe instances, organ failure. Recognizable symptoms and markers of sepsis encompass substantial elevations in body temperature, respiratory rate, hemoglobin levels, and alterations in immune cell counts, including neutrophils, monocytes, and basophils, along with increases in certain acute-phase proteins. In contrast to human medicine, veterinarians must take into account some species differences. This article provides a comprehensive overview of changes in the immune system during sepsis, placing particular emphasis on species variations and exploring potential future drugs and interventions. Hence, understanding the intricate balance of the immune responses during sepsis is crucial to develop effective treatments and interventions to improve the chances of recovery in animals suffering from this serious condition.
败血症仍然是动物和人类最常见的死亡原因之一。它的特征是对感染的异常免疫反应，导致广泛的炎症、器官功能障碍，在严重的情况下，还会导致器官衰竭。败血症的明显症状和标志物包括体温、呼吸频率、血红蛋白水平的显著升高，以及免疫细胞计数（包括中性粒细胞、单核细胞和嗜碱性粒细胞）的改变，同时某些急性期蛋白也会增加。与人类医学不同，兽医必须考虑到一些物种差异。本文全面概述了败血症期间免疫系统的变化，特别强调了物种差异，并探讨了潜在的未来药物和干预措施。因此，了解败血症期间免疫反应的复杂平衡对于开发有效的治疗和干预措施以提高患有这种严重疾病的动物的康复机会至关重要。
