Marquez-Arrico Julia E, Catalán-Aguilar Judit, Navarro José Francisco, Adan Ana
Department of Clinical Psychology and Psychobiology, School of Psychology, University of Barcelona, Passeig de la Vall d'Hebrón 171, 08035 Barcelona, Spain; Institute of Neurosciences, University of Barcelona, 08035 Barcelona, Spain.
Department of Psychobiology, Psychology Center, Universitat de València, Av. Blasco Ibáñez, 21, 46010 Valencia, Spain; Institut d'Investigació en Psicologia dels Recursos Humans, del Desenvolupament Organitzacional i de la Qualitat de Vida Laboral (Idocal), Universitat de València, Av. Blasco Ibáñez, 21, 46010 Valencia, Spain.
Prog Neuropsychopharmacol Biol Psychiatry. 2024 Aug 30;134:111085. doi: 10.1016/j.pnpbp.2024.111085. Epub 2024 Jul 11.
Substance Use Disorder (SUD) represents one of the most frequent conditions worldwide which commonly coexists with major depressive disorder (MDD). This comorbidity (SUD + MDD) is one of the most prevalent with patients showing certain social and clinical characteristics that could lead to a worsening of their cognitive performance. However, despite these particularities, only a few studies have addressed the possible differences in cognitive performance between patients with SUD + MDD compared with those with SUD-only patients. Therefore, the aim of this study is to examine the clinical and cognitive profile of patients with SUD + MDD vs. SUD-only who are in early remission phase. For this purpose, 271 male patients underwent a clinical and neuropsychological assessment (SUD + MDD group: N = 101; SUD-only group: N = 170). Results indicated that SUD + MDD patients showed worse cognitive performance than SUD in visuospatial reasoning, verbal memory and learning, recognition, and processing speed even after a 3-month period of abstinence. Furthermore, these patients exhibited more self-reported prefrontal symptoms, as well as worse social and clinical conditions. This study indicates that the neurocognitive and clinical profile of patients with SUD + MDD could represent a risk since their characteristics have been associated with poorer recovery and prognosis. Our results could be helpful in clinical practice highlighting the need for cognitive remediation strategies in these populations, providing information that would allow the implementation of more appropriate treatments and preventive strategies.
物质使用障碍（SUD）是全球最常见的疾病之一，通常与重度抑郁症（MDD）共存。这种共病情况（SUD + MDD）是最普遍的情况之一，患者表现出某些社会和临床特征，可能导致其认知能力下降。然而，尽管存在这些特殊性，但只有少数研究探讨了SUD + MDD患者与仅患有SUD的患者在认知能力方面可能存在的差异。因此，本研究的目的是检查处于早期缓解期的SUD + MDD患者与仅患有SUD的患者的临床和认知特征。为此，271名男性患者接受了临床和神经心理学评估（SUD + MDD组：N = 101；仅患有SUD组：N = 170）。结果表明，即使在禁欲3个月后，SUD + MDD患者在视觉空间推理、言语记忆和学习、识别及处理速度方面的认知能力仍比仅患有SUD的患者差。此外，这些患者表现出更多自我报告的前额叶症状，以及更差的社会和临床状况。本研究表明，SUD + MDD患者的神经认知和临床特征可能代表一种风险，因为他们的特征与较差的康复和预后相关。我们的结果可能有助于临床实践，强调这些人群需要认知康复策略，提供的信息将有助于实施更合适的治疗和预防策略。
