Organ Transplantation Center, Biruni University Hospital, İstanbul, Türkiye.
Radiology Department, İstanbul Aydın University Medical Park Florya Hospital, İstanbul, Türkiye.
Transplant Proc. 2024 Jul-Aug;56(6):1374-1377. doi: 10.1016/j.transproceed.2024.02.029. Epub 2024 Jul 14.
It was aimed to examine the overall role of cold ischemia time and anhepatic phase durations in terms of peroperative blood transfusion needs, hospital stay conditions and postoperative charges, and survival in recipients.
One hundred forty-eight adult living donor liver transplant recipients (18 years and older) were included in the study. Whether the anhepatic phase and cold ischemia duration have an effect on the rates of surgery time, blood product transfusion, total hospital and intensive care unit stay, postoperative biliary complications, hepatic vein thrombosis, portal vein thrombosis, early postoperative bleeding, sepsis, and primary graft dysfunction. Was analyzed statistically. In addition, the effect of the anhepatic phase and cold ischemia time on graft survival was statistically examined by creating an average of the patient follow-up period.
It was observed that the operation time increased statistically as the cold ischemia time increased (P = .000). No statistically significant relationship was found between other findings and cold ischemia time and anhepatic phase.
Prolonged surgery time due to increased cold ischemia time may be an important finding in terms of peroperative and postoperative results of the graft.
研究无肝期和冷缺血时间在术中输血需求、住院时间和费用以及受者存活率方面的总体作用。
本研究纳入了 148 例成年活体供肝移植受者（18 岁及以上）。统计分析无肝期和冷缺血时间对手术时间、输血量、总住院时间和重症监护病房停留时间、术后胆漏、肝静脉血栓形成、门静脉血栓形成、术后早期出血、脓毒症和原发性移植物功能障碍发生率的影响。此外，通过创建患者随访期的平均值，对无肝期和冷缺血时间对移植物存活率的影响进行了统计学检查。
观察到冷缺血时间的增加导致手术时间呈统计学增加（P=0.000）。其他发现与冷缺血时间和无肝期之间没有统计学显著关系。
由于冷缺血时间的延长导致手术时间延长，这可能是移植物围手术期和术后结果的一个重要发现。
