GBA branch of Aerospace Information Research Institute, Chinese Academy of Sciences, Guangzhou 510700, China; School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China; Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics, Guangzhou 510700, China.
GBA branch of Aerospace Information Research Institute, Chinese Academy of Sciences, Guangzhou 510700, China; Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics, Guangzhou 510700, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2024 Dec 5;322:124803. doi: 10.1016/j.saa.2024.124803. Epub 2024 Jul 10.
Chirality plays an important role in medicine, biology, and chemistry. Molecules of different chirality could display dramatically different medical effects, pharmacological activities, and physiological impacts. Ibuprofen is an important anti-inflammatory drug in clinics. The anti-inflammatory effect is almost solely attributed to the (S)-(+)-Ibuprofen, while its enantiomer (R)-(-)-Ibuprofen plays a negative effect on increasing the metabolic burden. In this work, a terahertz (THz) polarization-sensitive metasurface sensor is proposed for qualitative and quantitative identification of the chiral Ibuprofen. The chirality parameters of Ibuprofen are extracted from the circular-polarized transmission coefficients. The parameters are further used to simulate the coupling mechanism between the Ibuprofen and the sensor to explain the principle of recognition. The sensitivities of (R)-(-)-Ibuprofen and (S)-(+)-Ibuprofen are found to be 1.5 THz/(mg/L) and 1.8 THz/(mg/L) for the TM polarization, respectively, and 1.7 THz/(mg/L) and 2.1 THz/(mg/L) for the TE polarization, respectively. The difference enables the chirality identification according to the different frequency shift at the same concentration. The exceptional specificity and sensitivity provide a new avenue for chiral molecular recognition.
手性在医学、生物学和化学中起着重要作用。不同手性的分子可能表现出截然不同的医学效果、药理活性和生理影响。布洛芬是临床上一种重要的抗炎药。其抗炎作用几乎完全归因于（S）-（+）-布洛芬，而其对映异构体（R）-（-）-布洛芬则对增加代谢负担产生负面影响。在这项工作中，提出了一种太赫兹（THz）偏振敏感超表面传感器，用于定性和定量识别手性布洛芬。从圆偏振透射系数中提取布洛芬的手性参数。这些参数进一步用于模拟布洛芬与传感器之间的耦合机制，以解释识别原理。发现 TM 偏振下（R）-（-）-布洛芬和（S）-（+）-布洛芬的灵敏度分别为 1.5 THz/（mg/L）和 1.8 THz/（mg/L），TE 偏振下的灵敏度分别为 1.7 THz/（mg/L）和 2.1 THz/（mg/L）。这种差异使得根据相同浓度下的不同频移能够进行手性识别。这种特殊的特异性和灵敏度为手性分子识别提供了新的途径。
