Radboud university medical center, Department Intensive Care, Nijmegen, the Netherlands.
Radboud university medical center, Department Intensive Care, Nijmegen, the Netherlands.
J Crit Care. 2024 Dec;84:154858. doi: 10.1016/j.jcrc.2024.154858. Epub 2024 Jul 14.
To determine differences in one-year multi-domain health outcomes in COVID-19 and non-COVID-19 intensive care unit (ICU) survivors.
Adult ICU survivors treated for COVID-19 were compared to a control group consisting of survivors admitted for respiratory distress due to other causes, i.e. non-COVID-19 ARDS or pneumonia. Occurrence of physical (frailty, fatigue, physical symptoms), mental (anxiety, depression, post-traumatic stress) and cognitive symptoms, and quality of life (QoL) scores were measured, using validated questionnaires, before and one year after ICU treatment.
In total, 506 COVID-19 survivors could be compared to 228 non-COVID-19 survivors. At one-year follow-up, COVID-19 ICU survivors had less physical (76.2% vs. 86.9%, p = 0.001) and mental symptoms (32.0% vs. 47.1%, p < 0.001) than the control group. Cognitive symptoms were comparable (22.5% vs. 17.2%, p = 0.12). However, compared to pre-ICU health symptoms and scores, COVID-19 survivors experienced an increase in symptom occurrence rates in all domains and a decrease in QoL, whereas the control group only experienced an increase in mental and cognitive symptoms, with a similar QoL at one-year follow-up.
COVID-19 ICU survivors experience equal or less health problems but a greater decline in QoL one year after ICU admission compared to non-COVID-19 ARDS or pneumonia survivors.
确定 COVID-19 和非 COVID-19 重症监护病房（ICU）幸存者在一年多领域健康结果方面的差异。
将 COVID-19 治疗的 ICU 幸存者与对照组进行比较，对照组由因其他原因（即非 COVID-19 ARDS 或肺炎）呼吸窘迫而入院的幸存者组成。使用经过验证的问卷，在 ICU 治疗前后测量身体（虚弱、疲劳、身体症状）、精神（焦虑、抑郁、创伤后应激）和认知症状以及生活质量（QoL）评分的发生情况。
共有 506 例 COVID-19 幸存者可与 228 例非 COVID-19 幸存者进行比较。在一年的随访中，COVID-19 ICU 幸存者的身体症状（76.2% vs. 86.9%，p = 0.001）和精神症状（32.0% vs. 47.1%，p < 0.001）少于对照组。认知症状相当（22.5% vs. 17.2%，p = 0.12）。然而，与 ICU 前的健康症状和评分相比，COVID-19 幸存者在所有领域的症状发生率都增加，而 QoL 下降，而对照组仅在精神和认知症状方面增加，一年后的 QoL 相似。
与非 COVID-19 ARDS 或肺炎幸存者相比，COVID-19 ICU 幸存者在 ICU 入住一年后，健康问题同等或更少，但 QoL 下降更大。
