Brioschi Federica Alessandra, Rabbogliatti Vanessa, Auletta Luigi, Ravasio Giuliano, Amari Martina, Elia Luigi, Gritti Ilaria, Ferrari Francesco
Department of Veterinary Medicine and Animal Sciences, University of Milan, Milan, Italy.
Free Practitioner, Bergamo, Italy.
Res Vet Sci. 2024 Sep;177:105355. doi: 10.1016/j.rvsc.2024.105355. Epub 2024 Jul 10.
The study aimed to compare the quality of perioperative analgesia, the motor block duration, and the effects on main cardiovascular parameters of dexmedetomidine (1 μg/kg/nerve block) or magnesium sulphate (2 mg/kg/nerve block) as adjuvants to 0.3% ropivacaine for sciatic and saphenous nerves block in dogs undergoing tibial plateau leveling osteotomy (TPLO). Dogs randomly received perineural dexmedetomidine-ropivacaine (D group), magnesium sulphate-ropivacaine (M group), or ropivacaine (C group). Fentanyl was administered in case of intraoperative nociception. Postoperative pain was assessed using the Short Form-Glasgow Composite Measure Pain Scale (SF-GCMPS) and VAS scale. The duration of motor blockade and intra- and postoperative cardiovascular parameters were also recorded. Group M required significantly more fentanyl than D group (p = 0.04). Group M had a significantly higher SF-GCMPS score than group C at 4 (p = 0.002) and 5 h after extubation (p = 0.01), and a significantly higher VAS score than group D at 3 h after extubation (p = 0.03), and at 4 h if compared to group C (p = 0.009). No significant differences regarding the duration of motor blockade were detected between groups (p = 0.07). The heart rate was significantly lower in group D than in M and C groups intraoperatively and during the first 1.5 h post extubation. The addition of dexmedetomidine or magnesium sulphate as adjuvants to perineural ropivacaine did not improve the quality of perioperative analgesia and did not prolong the motor blockade in dogs undergoing sciatic and saphenous nerves block for TPLO surgery.
本研究旨在比较右美托咪定（1μg/kg/神经阻滞）或硫酸镁（2mg/kg/神经阻滞）作为辅助剂与0.3%罗哌卡因用于接受胫骨平台水平截骨术（TPLO）的犬坐骨神经和隐神经阻滞时的围手术期镇痛质量、运动阻滞持续时间以及对主要心血管参数的影响。犬随机接受神经周围注射右美托咪定 - 罗哌卡因（D组）、硫酸镁 - 罗哌卡因（M组）或罗哌卡因（C组）。术中出现伤害性感受时给予芬太尼。使用简短格拉斯哥综合疼痛量表（SF - GCMPS）和视觉模拟评分量表（VAS）评估术后疼痛。还记录了运动阻滞的持续时间以及术中和术后的心血管参数。M组所需芬太尼明显多于D组（p = 0.04）。M组在拔管后4小时（p = 0.002）和5小时（p = 0.01）的SF - GCMPS评分显著高于C组，在拔管后3小时（p = 0.03）以及与C组相比在4小时（p = 0.009）时的VAS评分显著高于D组。各组之间在运动阻滞持续时间方面未检测到显著差异（p = 0.07）。术中及拔管后的前1.5小时，D组的心率明显低于M组和C组。在接受TPLO手术的犬坐骨神经和隐神经阻滞中，将右美托咪定或硫酸镁作为神经周围罗哌卡因的辅助剂并不能改善围手术期镇痛质量，也不能延长运动阻滞时间。
