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微血管减压术后复发三叉神经痛的治疗:如何选择。

Treatment of recurrent trigeminal neuralgia after microvascular decompression: How to select.

机构信息

First People's Hospital of Ningyang County, Tai'an, Shandong, China; Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

出版信息

J Clin Neurosci. 2024 Aug;126:313-318. doi: 10.1016/j.jocn.2024.07.005. Epub 2024 Jul 13.

Abstract

BACKGROUND

This study aimed to investigate individualized treatment strategies and clinical outcomes in patients with recurrent trigeminal neuralgia after undergoing microvascular decompression (MVD).

METHODS

One hundred forty-four patients with recurrent trigeminal neuralgia after MVD were retrospectively examined and grouped according to treatment. Surgical efficacy and pain recurrence were analyzed as outcomes.

RESULTS

Repeat craniotomy was performed in 31 patients (21.5 %), percutaneous balloon compression (PBC) in 67 (46.5 %), and radiofrequency thermocoagulation (RFT) in 46 (32.0 %). Effectiveness did not differ among the three types of treatment (P = 0.052). The incidence of postoperative complications, including trigeminal nerve cardiac reflex, facial numbness, and mastication weakness, was lower in the craniotomy group than the PBC and RFT groups (P < 0.001). The 5-year pain recurrence rate was significantly higher than the 1-year rate in all groups. Although the 1-year pain recurrence rate did not differ among the groups, the 5-year rate was significantly lower in the repeat craniotomy group than the other groups (P < 0.001).

CONCLUSION

Patients with recurrent trigeminal neuralgia after MVD should be treated based on imaging evaluation and general condition. Repeat craniotomy, PBC, and RFT are all effective. Incidence of postoperative complications and long-term pain recurrence-free survival are superior for repeat craniotomy.

摘要

背景

本研究旨在探讨微血管减压术(MVD)后复发三叉神经痛患者的个体化治疗策略和临床结局。

方法

回顾性分析 144 例 MVD 后复发三叉神经痛患者,根据治疗方法分组。分析手术疗效和疼痛复发作为结局。

结果

31 例(21.5%)患者行再次开颅手术,67 例(46.5%)行经皮球囊压迫术(PBC),46 例(32.0%)行射频热凝术(RFT)。三种治疗方法的疗效无差异(P=0.052)。开颅手术组术后并发症发生率(三叉神经心脏反射、面部麻木和咀嚼无力)低于 PBC 和 RFT 组(P<0.001)。所有组的 5 年疼痛复发率均明显高于 1 年。虽然各组的 1 年疼痛复发率无差异,但重复开颅组的 5 年疼痛复发率明显低于其他组(P<0.001)。

结论

MVD 后复发三叉神经痛患者应根据影像学评估和一般情况进行治疗。再次开颅手术、PBC 和 RFT 均有效。术后并发症发生率和长期无疼痛复发的生存情况,重复开颅手术更佳。

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