Department of Otolaryngology-Head & Neck Surgery, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Department of Breast Disease, Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
Neurosci Lett. 2024 Jul 27;836:137897. doi: 10.1016/j.neulet.2024.137897. Epub 2024 Jul 14.
The efficacy of vitamin C in age-related hearing loss, i.e., presbycusis, remains debatable. On a separate note, inflammation induced by the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is involved in the progression of presbycusis. In this study, we investigated the effect of vitamin C on male C57BL/6 mice's presbycusis and NLRP3 inflammasome. The results showed that vitamin C treatment improved hearing, reduced the production of inflammatory factors, inhibited NLRP3 inflammasome activation, and decreased cytosolic mitochondrial DNA (mtDNA) in the C57BL/6 mouse cochlea, inferior colliculus, and auditory cortex. According to this study, vitamin C protects auditory function in male C57BL/6 presbycusis mice through reducing mtDNA release, inhibiting the NLRP3 inflammasome activation in the auditory pathway. Our study provides a theoretical basis for applying vitamin C to treat presbycusis.
维生素 C 对年龄相关性听力损失（即老年性聋）的疗效仍存在争议。另一方面，NOD 样受体家族 pyrin 结构域包含 3（NLRP3）炎性小体引起的炎症参与了老年性聋的进展。在这项研究中，我们研究了维生素 C 对雄性 C57BL/6 小鼠老年性聋和 NLRP3 炎性小体的影响。结果表明，维生素 C 治疗可改善听力，减少炎症因子的产生，抑制 NLRP3 炎性小体的激活，并减少 C57BL/6 小鼠耳蜗、下丘和听觉皮层中的细胞质线粒体 DNA（mtDNA）。根据这项研究，维生素 C 通过减少 mtDNA 释放，抑制听觉通路中 NLRP3 炎性小体的激活，来保护雄性 C57BL/6 老年性聋小鼠的听觉功能。我们的研究为应用维生素 C 治疗老年性聋提供了理论依据。
