一般人群的血清脂肪酸谱和神经丝轻链水平。

Serum Fatty Acid Profiles and Neurofilament Light Chain Levels in the General Population.

机构信息

Department of Epidemiology, School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen, China.

出版信息

J Nutr. 2024 Oct;154(10):3070-3078. doi: 10.1016/j.tjnut.2024.07.007. Epub 2024 Jul 14.

DOI:10.1016/j.tjnut.2024.07.007

PMID:39004226

Abstract

BACKGROUND

Previous studies have demonstrated associations between fatty acids and neurological disorders. However, no studies have examined the relationship between serum fatty acid levels and serum neurofilament light chain (NfL), a biomarker of neurological disorders.

OBJECTIVES

This study aimed to comprehensively investigate the intricate relationship between 30 serum fatty acids and serum NfL levels in a nationally representative sample of United States adults, using data from the 2013-2014 National Health and Nutrition Examination Survey.

METHODS

Using a cross-sectional analysis, multivariable linear regression models were used to explore the associations between 30 serum fatty acids and serum NfL levels. This analysis involved adjustment for potential confounding variables, including age, sex, race, body mass index (BMI), smoking status, hyperlipidemia, and diabetes, to clarify the association between serum fatty acids and serum NfL levels.

RESULTS

The analysis revealed that certain fatty acids exhibited distinct associations with serum NfL levels. Notably, docosanoic acid (22:0) and tricosanoic acid (C23:0) were found to be inversely associated with serum NfL levels (β = -0.280, 95% confidence interval [CI]: -0.525, -0.035; β = -0.292, 95% CI: -0.511, -0.072). Conversely, palmitoleic acid (16:1n-7) demonstrated a positive association with serum NfL levels (β = 0.125, 95% CI: 0.027, 0.222). Notably, these associations remained significant even after adjustment for potential confounders.

CONCLUSIONS

Individuals with high relative concentrations of certain SFA exhibited decreased serum NfL, whereas those with high relative concentrations of certain monounsaturated fatty acids showed increased serum NfL. These findings contribute to a deeper understanding of the potential impact of serum fatty acids on NfL levels, shedding light on novel avenues for further investigation and potential interventions in the context of neurological health.

摘要

背景

先前的研究已经证实了脂肪酸与神经紊乱之间存在关联。然而，目前尚无研究探讨血清脂肪酸水平与神经丝轻链（NfL）之间的关系，而 NfL 是神经紊乱的生物标志物。

目的

本研究旨在通过使用 2013-2014 年全国健康和营养调查的数据，全面研究美国成年人全国代表性样本中 30 种血清脂肪酸与血清 NfL 水平之间复杂的关系。

方法

采用横断面分析，多元线性回归模型用于探究 30 种血清脂肪酸与血清 NfL 水平之间的关联。本分析中进行了潜在混杂变量的调整，包括年龄、性别、种族、体重指数（BMI）、吸烟状况、血脂异常和糖尿病，以明确血清脂肪酸与血清 NfL 水平之间的关联。

结果

分析表明，某些脂肪酸与血清 NfL 水平具有明显的相关性。值得注意的是，二十二烷酸（22:0）和二十三烷酸（C23:0）与血清 NfL 水平呈负相关（β=-0.280，95%置信区间[CI]：-0.525，-0.035；β=-0.292，95%CI：-0.511，-0.072）。相反，棕榈油酸（16:1n-7）与血清 NfL 水平呈正相关（β=0.125，95%CI：0.027，0.222）。值得注意的是，即使在调整了潜在混杂因素后，这些关联仍然具有统计学意义。