Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA.
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, USA; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA.
Ann Epidemiol. 2024 Sep;97:11-15. doi: 10.1016/j.annepidem.2024.07.042. Epub 2024 Jul 14.
Transgender and gender-diverse (TGD) people may have been disproportionately impacted by the COVID-19 pandemic, yet little is known about vaccination status in this population. This multicenter cohort study of insured adults examined the rates of COVID-19 vaccine initiation and completion in TGD persons compared to matched cisgender persons.
A cohort of TGD persons and matched cisgender persons enrolled in Kaiser Permanente health plans in Northern and Southern California between 12/1/2020 and 7/31/2021 were analyzed. COVID-19 vaccination initiation and completion rates were compared across groups using Cox regression models.
Among transmasculine persons, the HR (95 % CI) estimates for COVID-19 vaccination initiation and completion were, respectively, 1.35 (1.30-1.40) and 1.78 (1.71-1.85) compared with cisgender women and 1.34 (1.29-1.40) and 1.81 (1.73-1.88) compared with cisgender men. Among transfeminine persons, the corresponding HRs (95 % CIs) for vaccination initiation and completion were 1.35 (1.30-1.40) and 1.78 (1.71-1.85) compared with cisgender women and 1.34 (1.29-1.40) and 1.81 (1.73-1.88) compared with cisgender men.
Findings from this cohort of insured adults demonstrated that TGD persons initiated and completed COVID-19 vaccination at higher rates compared to matched cisgender persons. Further work is needed to understand vaccination rates and determinants in the broader TGD populations.
跨性别和性别多样化（TGD）人群可能 disproportionately 受到了 COVID-19 大流行的影响，但人们对这一人群的疫苗接种情况知之甚少。本项多中心队列研究对参保成年人进行了调查，比较了 TGD 人群与匹配的顺性别人群的 COVID-19 疫苗接种起始率和完成率。
对 2020 年 12 月 1 日至 2021 年 7 月 31 日期间参加 Kaiser Permanente 健康计划的 TGD 人群和匹配的顺性别人群进行了队列研究。使用 Cox 回归模型比较了不同组之间 COVID-19 疫苗接种起始率和完成率。
在跨性别男性中，COVID-19 疫苗接种起始和完成率的 HR（95%CI）估计值分别为 1.35（1.30-1.40）和 1.78（1.71-1.85），与顺性别女性相比；与顺性别男性相比，分别为 1.34（1.29-1.40）和 1.81（1.73-1.88）。在跨性别女性中，疫苗接种起始和完成率的相应 HR（95%CI）分别为 1.35（1.30-1.40）和 1.78（1.71-1.85），与顺性别女性相比；与顺性别男性相比，分别为 1.34（1.29-1.40）和 1.81（1.73-1.88）。
本项参保成年人队列研究的结果表明，TGD 人群与匹配的顺性别人群相比，COVID-19 疫苗接种起始率和完成率更高。需要进一步开展工作，以了解更广泛的 TGD 人群中的疫苗接种率和决定因素。
