Department of clinical medicine, University of Copenhagen, Copenhagen, Denmark; Department of Gynaecology, Fertility and Obstetrics, Rigshospitalet, Copenhagen, Denmark.
Department of Economy, University of Copenhagen, Copenhagen, Denmark.
J Obstet Gynaecol Can. 2024 Sep;46(9):102612. doi: 10.1016/j.jogc.2024.102612. Epub 2024 Jul 14.
Little is known about whether induced abortions are associated with the final lifetime number of live births (life births). The objective of this study was to examine the association between the number of life births with the number of abortions a female has had in her lifetime.
In a national cohort design, we followed all Danish females from ages 15 to 44 years through the period 1977-2017 for induced abortions and live births. For each lifetime number of induced abortions, the average number of life births was assessed, and rates with 95% CI were calculated.
The study included 409 497 females who completed 222 482 induced abortions and 831 742 live births. Of 265 573 (64.9%) females who did not have any induced abortion, the average number of life births was 2.09 (95% CI 2.08-2.10). For females with 1 (23.4%), 2 (7.4%), 3 (2.6%), 4 (1.0%), and ≥5 (0.7%) induced abortions during their reproductive lifespan, the average number of life births was 1.88 (1.87-1.89), 1.99 (1.98-2.00), 2.09 (2.06-2.11), 2.13 (2.09-2.15), and 2.25 (2.21-2.29), respectively. The increase in number of life births in females with 1 to females with 5+ induced abortions was 4.7% for each additional induced abortion.
We found the number of induced abortions during a woman's reproductive lifespan to be positively correlated to the number of live births. This association is likely explained by a high fecundity in females with multiple pregnancies including induced abortions and suggests that even several induced abortions do not compromise a woman's general reproductive end points.
关于人工流产是否与女性终生活产数量(活产)有关,目前知之甚少。本研究旨在探讨女性一生中人工流产次数与活产次数之间的关系。
采用全国队列设计,我们对 1977 年至 2017 年期间所有年龄在 15 至 44 岁的丹麦女性进行了随访,以记录人工流产和活产情况。对于每一生育次数的人工流产,评估平均活产次数,并计算了 95%置信区间的率。
研究纳入了 409497 名女性,她们共完成了 222482 次人工流产和 831742 次活产。在 265573 名(64.9%)没有任何人工流产的女性中,平均活产数为 2.09(95%CI 2.08-2.10)。在生育期有 1(23.4%)、2(7.4%)、3(2.6%)、4(1.0%)和≥5(0.7%)次人工流产的女性中,平均活产数分别为 1.88(1.87-1.89)、1.99(1.98-2.00)、2.09(2.06-2.11)、2.13(2.09-2.15)和 2.25(2.21-2.29)。随着人工流产次数的增加,从有 1 次人工流产到有 5 次及以上人工流产的女性,每增加一次人工流产,活产数增加 4.7%。
我们发现女性生育期内的人工流产次数与活产数量呈正相关。这种关联可能是由多次妊娠(包括人工流产)的女性较高的生育能力所解释的,这表明即使多次人工流产也不会影响女性的总体生育终点。