卵母细胞激活联合纺锤体观察下卵胞浆内单精子注射对低受精率患者的生育结局的影响。
The fertility outcome of assisted oocyte activation combined with spindle view-assisted intracytoplasmic sperm injection in patients with low fertilization rate.
机构信息
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taiwan.
Fertility and Reproductive Genetic Center, Chang Gung Memorial Hospital, Taiwan.
出版信息
Taiwan J Obstet Gynecol. 2024 Jul;63(4):513-517. doi: 10.1016/j.tjog.2023.10.017.
OBJECTIVE
To examine the possible synergic effect of spindle view-assisted intracytoplasmic sperm injection (SV-ICSI) with assisted oocyte activation (AOA) for low fertilization rate.
MATERIALS AND METHODS
A single-center retrospective study from 2019/09-2023/06, a total of 47 patients, autologous IVF cycle, and low fertilization rate history, including control group (SV-ICSI, 33 patients) and intervention group (AOA-SV-ICSI, 14 patients), comparing fertilization rate, blastocyst formation rate, and clinical pregnancy rate.
RESULTS
The blastocyst formation rate was significantly higher (p = 0.020) in the AOA-SV-ICSI group than in the SV-ICSI group. The fertilization rate (P = 0.468) and clinical pregnancy rate (p = 0.057) were non-significant between groups.
CONCLUSION
The AOA-SV-ICSI group's blastocyst formation rate significantly improved in patients with previous low fertilization rates, which might help them obtain more useable embryos for further embryo implantation.
目的
探讨纺锤体视图辅助卵胞浆内单精子注射（SV-ICSI）联合辅助卵母细胞激活（AOA）对低受精率的协同作用。
材料与方法
这是一项 2019 年 9 月至 2023 年 6 月的单中心回顾性研究，共纳入 47 名患者，均为自体 IVF 周期，且有低受精率史，包括对照组（SV-ICSI，33 例）和干预组（AOA-SV-ICSI，14 例），比较两组的受精率、囊胚形成率和临床妊娠率。
结果
AOA-SV-ICSI 组的囊胚形成率显著高于 SV-ICSI 组（p=0.020）。两组间的受精率（P=0.468）和临床妊娠率（p=0.057）无显著差异。
结论
对于既往受精率低的患者，AOA-SV-ICSI 组的囊胚形成率显著提高，这可能有助于他们获得更多可用的胚胎进行进一步的胚胎移植。
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