Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taiwan.
Fertility and Reproductive Genetic Center, Chang Gung Memorial Hospital, Taiwan.
Taiwan J Obstet Gynecol. 2024 Jul;63(4):513-517. doi: 10.1016/j.tjog.2023.10.017.
To examine the possible synergic effect of spindle view-assisted intracytoplasmic sperm injection (SV-ICSI) with assisted oocyte activation (AOA) for low fertilization rate.
A single-center retrospective study from 2019/09-2023/06, a total of 47 patients, autologous IVF cycle, and low fertilization rate history, including control group (SV-ICSI, 33 patients) and intervention group (AOA-SV-ICSI, 14 patients), comparing fertilization rate, blastocyst formation rate, and clinical pregnancy rate.
The blastocyst formation rate was significantly higher (p = 0.020) in the AOA-SV-ICSI group than in the SV-ICSI group. The fertilization rate (P = 0.468) and clinical pregnancy rate (p = 0.057) were non-significant between groups.
The AOA-SV-ICSI group's blastocyst formation rate significantly improved in patients with previous low fertilization rates, which might help them obtain more useable embryos for further embryo implantation.
探讨纺锤体视图辅助卵胞浆内单精子注射（SV-ICSI）联合辅助卵母细胞激活（AOA）对低受精率的协同作用。
这是一项 2019 年 9 月至 2023 年 6 月的单中心回顾性研究，共纳入 47 名患者，均为自体 IVF 周期，且有低受精率史，包括对照组（SV-ICSI，33 例）和干预组（AOA-SV-ICSI，14 例），比较两组的受精率、囊胚形成率和临床妊娠率。
AOA-SV-ICSI 组的囊胚形成率显著高于 SV-ICSI 组（p=0.020）。两组间的受精率（P=0.468）和临床妊娠率（p=0.057）无显著差异。
对于既往受精率低的患者，AOA-SV-ICSI 组的囊胚形成率显著提高，这可能有助于他们获得更多可用的胚胎进行进一步的胚胎移植。
