Deguchi K, Fukayama S, Nishimura Y, Nishike A, Oda S, Sato S, Matsumoto Y, Ikegami R, Yokota N, Tanaka S
Jpn J Antibiot. 1985 Jun;38(6):1587-602.
In vitro activity of antimicrobial agents such as ABPC, SBPC, MPC, CEZ, CTM, CMZ, CTX, CMX, CZX, LMOX, CPZ, CFS and GM against major clinical isolates, S. aureus, S. pyogenes, E. coli, K. pneumoniae, P. mirabilis, C. freundii, Enterobacter spp., S. marcescens, P. vulgaris and P. aeruginosa, was examined. In this paper, we will report the susceptibility of S. aureus, S. pyogenes, E. coli, K. pneumoniae and P. mirabilis during a three-year period, 1981 to approximately 1983. CEZ- and GM-resistant S. aureus has markedly increased and occupied 24% and 18%, respectively, in 1983. CMZ and CFS have showed potent activity against CEZ-resistant S. aureus. It seems that the abuse of third generation-cephems and new oral cephalosporins is closely related with the increase of cephems-resistant S. aureus. The penicillin- and cephem-resistant strains of S. pyogenes could not be found in our study. Quite a few strains of E. coli, K. pneumoniae and P. mirabilis are resistant to penicillins, and also there is no appreciable change in susceptibility. Some strains of E. coli, K. pneumoniae and P. mirabilis showed low susceptibility to CPZ, but all strains showed high susceptibility and no change in susceptibility to third generations, and these strains showed no tendency to decrease in susceptibility to GM.
研究了抗菌药物如氨比西林（ABPC）、磺苄西林（SBPC）、美洛西林（MPC）、头孢唑肟（CEZ）、头孢特仑（CTM）、头孢米诺（CMZ）、头孢噻肟（CTX）、头孢克肟（CMX）、头孢丙烯（CZX）、拉氧头孢（LMOX）、头孢哌酮（CPZ）、头孢磺啶（CFS）和庆大霉素（GM）对主要临床分离株金黄色葡萄球菌、化脓性链球菌、大肠杆菌、肺炎克雷伯菌、奇异变形杆菌、弗氏柠檬酸杆菌、肠杆菌属、粘质沙雷氏菌、普通变形杆菌和铜绿假单胞菌的体外活性。在本文中，我们将报告1981年至大约1983年这三年间金黄色葡萄球菌、化脓性链球菌、大肠杆菌、肺炎克雷伯菌和奇异变形杆菌的药敏情况。耐CEZ和GM的金黄色葡萄球菌显著增加，在1983年分别占24%和18%。CMZ和CFS对耐CEZ的金黄色葡萄球菌显示出强效活性。似乎第三代头孢菌素和新型口服头孢菌素的滥用与耐头孢菌素金黄色葡萄球菌的增加密切相关。在我们的研究中未发现化脓性链球菌的耐青霉素和耐头孢菌素菌株。相当多的大肠杆菌、肺炎克雷伯菌和奇异变形杆菌菌株对青霉素耐药，药敏情况也没有明显变化。一些大肠杆菌、肺炎克雷伯菌和奇异变形杆菌菌株对CPZ敏感性较低，但所有菌株对第三代药物敏感性高且药敏无变化，并且这些菌株对GM的敏感性没有降低的趋势。
