Department of Head Neck and Thyroid, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, China.
Sci Rep. 2024 Jul 14;14(1):16230. doi: 10.1038/s41598-024-66179-7.
Our objective was to examine the impact of elective neck dissection (END) on the prognosis of patients with cT2N0 maxillary sinus squamous cell carcinoma (MS-SCC) and to determine factors that predict the occurrence of occult metastasis in this patient population. A retrospective analysis was conducted using data from the SEER database. Patients with cT2N0 MS-SCC were included in the study and divided into two groups: those who received END and those who did not. The impact of END on disease-specific survival (DSS) and overall survival (OS) was assessed using propensity score matching. Multivariate logistic regression analysis was performed to determine predictors for occult metastasis. A total of 180 patients were included in the study, with 40 cases receiving END. Following propensity score matching, patients treated with END and those without showed similar DSS and OS rates. Occult metastasis was observed in 9 patients, corresponding to a rate of 22.5%. High-grade tumors were independently associated with a higher risk of occult metastasis compared to low-grade tumors (hazard ratio 1.52, 95% confidence interval 1.17-2.00). cT2 MS-SCC carries an occult metastasis rate of 22.5%, with histologic grade being the primary determinant of occult metastasis. END does not confer a significant survival benefit in this patient population.
我们的目的是研究选择性颈部清扫术（END）对 cT2N0 上颌窦鳞状细胞癌（MS-SCC）患者预后的影响，并确定预测该患者人群隐匿性转移发生的因素。本研究采用 SEER 数据库中的数据进行回顾性分析。纳入 cT2N0 MS-SCC 患者，并分为两组：接受 END 的患者和未接受 END 的患者。使用倾向评分匹配评估 END 对疾病特异性生存（DSS）和总生存（OS）的影响。采用多变量逻辑回归分析确定隐匿性转移的预测因素。共纳入 180 例患者，其中 40 例接受 END。经倾向评分匹配后，接受 END 治疗的患者与未接受 END 治疗的患者的 DSS 和 OS 率相似。9 例患者发生隐匿性转移，占比 22.5%。与低级别肿瘤相比，高级别肿瘤与隐匿性转移的风险增加独立相关（风险比 1.52，95%置信区间 1.17-2.00）。cT2 MS-SCC 的隐匿性转移率为 22.5%，组织学分级是隐匿性转移的主要决定因素。在该患者人群中，END 并未带来显著的生存获益。
