Agahi Sadaf, Amouzegar Atieh, Honarvar Mohammadjavad, Azizi Fereidoun, Mehran Ladan
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, Tehran, I. R. of Iran.
Thyroid Res. 2024 Jul 15;17(1):14. doi: 10.1186/s13044-024-00201-y.
Understanding the relationship of thyroid hormones with the development of chronic kidney disease (CKD) has important clinical implications for managing patients with both thyroid and kidney dysfunction. In this review, our purpose was to provide a thorough comprehension of the interplay between thyroid hormones, thyroid dysfunctions, and CKD. While there is evidence linking thyroid hormone levels to renal diseases, the association between thyroid hormones, specifically within the normal range, and the risk of CKD incidence is still a subject of debate. The Google Scholar, PubMed, Scopus, and Web of Science, were searched using the medical subject heading (MeSH) terms for the relevant keywords up to December 2023.
Based on the review, the development of CKD is more consistently associated with higher serum TSH and thereafter lower serum free T3 levels; however, its association with free T4 is more controversial. Furthermore, subclinical and overt hypothyroidisms were considerably associated with incident CKD. Hyperthyroidism and Hashimoto thyroiditis might increase the risk of CKD.
了解甲状腺激素与慢性肾脏病（CKD）发生发展之间的关系，对于治疗甲状腺和肾脏功能均有障碍的患者具有重要的临床意义。在本综述中，我们旨在全面理解甲状腺激素、甲状腺功能障碍与CKD之间的相互作用。虽然有证据表明甲状腺激素水平与肾脏疾病有关，但甲状腺激素，特别是在正常范围内，与CKD发病风险之间的关联仍存在争议。截至2023年12月，使用医学主题词（MeSH）术语在谷歌学术、PubMed、Scopus和科学网中搜索相关关键词。
基于该综述，CKD的发生发展更一致地与较高的血清促甲状腺激素（TSH）以及随后较低的血清游离三碘甲状腺原氨酸（T3）水平相关；然而，其与游离甲状腺素（T4）的关联更具争议性。此外，亚临床和显性甲状腺功能减退与CKD的发生密切相关。甲状腺功能亢进症和桥本甲状腺炎可能会增加CKD的风险。
