Archana Kanderi, Mani Sumithra
Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, VISTAS, Tamil Nadu, India.
Curr Drug Res Rev. 2025;17(1):10-18. doi: 10.2174/0125899775309331240607105830.
Cytomegalovirus (CMV) is a prevalent virus across the world that belongs to the family Herpesviridae but remains dormant in the body unless the immune system is compromised. In addition, when the bacterium is compromised without any health risks, the infection spreads from one person to another person through body fluids, such as saliva, blood, etc. Ganciclovir is an anti- viral medication used in treating viral infections, especially in the treatment of CMV in people with acquired immune deficiency syndrome and immunity at risk. The quality control of ganciclovir in industries is carried out by using anti-green solvents in large volumes; these solvents are not safe in consideration of environmental factors and analysts. Also, the waste generation by these solvents causes hazardous effects on the environment. Further, using 12 green analytical chemistry principles promotes the awareness of analytical judgments among the research groups. It is a revolutionary step in the analytical field to enhance the safety of the environment, and analysts, apart from safety, help to control waste production and conserve energy-reducing occupational hazards. Many works have been carried out for the quality control of ganciclovir using different solvents, such as acetonitrile, methanol, etc. Despite this, there are no existing methods with green solvents or procedures to reduce energy and waste generation. Therefore, the purpose of this review is to understand the drug profile of ganciclovir and the methods developed.
巨细胞病毒（CMV）是一种在全球广泛流行的病毒，属于疱疹病毒科，在免疫系统未受损时会潜伏在体内。此外，当机体免疫系统受损且无其他健康风险时，该病毒会通过体液（如唾液、血液等）在人与人之间传播。更昔洛韦是一种用于治疗病毒感染的抗病毒药物，尤其用于治疗获得性免疫缺陷综合征患者和有免疫风险人群的巨细胞病毒感染。工业上对更昔洛韦的质量控制是通过大量使用非绿色溶剂来进行的；考虑到环境因素和分析人员，这些溶剂并不安全。此外，这些溶剂产生的废物会对环境造成危害。此外，运用12条绿色分析化学原则可提高研究团队对分析判断的认识。这是分析领域的一个革命性举措，旨在提高环境安全性，对于分析人员而言，除了安全之外，还有助于控制废物产生和节约能源，减少职业危害。已经开展了许多使用不同溶剂（如乙腈、甲醇等）对更昔洛韦进行质量控制的工作。尽管如此，目前尚无使用绿色溶剂或程序来减少能源消耗和废物产生的方法。因此，本综述的目的是了解更昔洛韦的药物概况以及已开发的方法。
