Korkushko O V, Asinova M I, Ershova G S
Kardiologiia. 1985 Jun;25(6):33-6.
The sensitivity of the renin-angiotensin-aldosterone system (RAAS) to regulatory sympathoadrenal and hypothalamo-pituitary effects was shown to increase with advancing age, in spite of declining plasma renin and aldosterone baselines. At the same time, this humoral mechanism was no longer capable of responding as adequately to potent stimuli, such as submaximum physical stress. The data obtained suggest that the RASS might act as a trigger mechanism underlying a greater incidence of essential hypertension in old age.
肾素-血管紧张素-醛固酮系统（RAAS）对调节性交感肾上腺及下丘脑-垂体效应的敏感性虽随年龄增长而血浆肾素和醛固酮基线下降，但仍显示增加。与此同时，这种体液机制对如次最大体力应激等强效刺激的反应能力不再充分。所获数据表明，RAAS可能是老年原发性高血压发病率更高的潜在触发机制。
