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丘脑底核深部脑刺激引发的情绪升高：一份录像病例报告。

Elevated Mood Induced by Subthalamic Nucleus Deep Brain Stimulation: A Video-Recorded Case Report.

机构信息

Department of Neurology, University of Florida, Gainesville, FL, USA.

Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.

出版信息

Tremor Other Hyperkinet Mov (N Y). 2024 Jul 12;14:37. doi: 10.5334/tohm.900. eCollection 2024.

DOI:10.5334/tohm.900
PMID:39005242
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11243764/
Abstract

BACKGROUND

Deep brain stimulation (DBS) can be an effective therapy to control motor signs in patients with Parkinson's disease (PD). However, subthalamic nucleus (STN) DBS can induce undesirable psychiatric adverse effects, including elevated mood.

CASE REPORT

We reported a video case of a 73-year-old male implanted with bilateral STN DBS who experienced stimulation-induced elevated mood. A correlation between mood changes and enhanced activation of the ventromedial region in the left STN was observed.

DISCUSSION

This video case report illustrates STN DBS-induced elevated mood and enhances early symptom recognition for patients and diagnostic awareness for professionals.

摘要

背景

深部脑刺激（DBS）可以有效控制帕金森病（PD）患者的运动症状。然而，丘脑底核（STN）DBS 可引起不良的精神副作用，包括情绪升高。

病例报告

我们报告了一例 73 岁男性双侧 STN-DBS 植入术后出现刺激诱导的情绪升高的视频病例。观察到情绪变化与左 STN 腹内侧区域的增强激活之间存在相关性。

讨论

本视频病例报告说明了 STN-DBS 诱导的情绪升高，并增强了患者的早期症状识别和专业人员的诊断意识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f03/11243764/eb664ea0c9b8/tohm-14-1-900-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f03/11243764/eb664ea0c9b8/tohm-14-1-900-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f03/11243764/eb664ea0c9b8/tohm-14-1-900-g1.jpg

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本文引用的文献

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Deep brain stimulation for Parkinson's disease.脑深部电刺激术治疗帕金森病。
J Intern Med. 2022 Nov;292(5):764-778. doi: 10.1111/joim.13541. Epub 2022 Jul 13.
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Prevalence and clinical aspects of depression in Parkinson's disease: A systematic review and meta‑analysis of 129 studies.帕金森病中抑郁的患病率和临床特征：129 项研究的系统评价和荟萃分析。
Neurosci Biobehav Rev. 2022 Oct;141:104749. doi: 10.1016/j.neubiorev.2022.104749. Epub 2022 Jun 21.
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Limbic Stimulation Drives Mania in STN-DBS in Parkinson Disease: A Prospective Study.
边缘刺激导致帕金森病 STN-DBS 中的躁狂：一项前瞻性研究。
Ann Neurol. 2022 Sep;92(3):411-417. doi: 10.1002/ana.26434. Epub 2022 Jul 12.
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Subthalamic and pallidal deep brain stimulation for Parkinson's disease-meta-analysis of outcomes.丘脑底核和苍白球深部脑刺激治疗帕金森病——疗效的荟萃分析
NPJ Parkinsons Dis. 2021 Sep 6;7(1):77. doi: 10.1038/s41531-021-00223-5.
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Elevated Mood States in Patients With Parkinson's Disease Treated With Deep Brain Stimulation: Diagnosis and Management Strategies.帕金森病患者接受深部脑刺激治疗后情绪状态升高：诊断和管理策略。
J Neuropsychiatry Clin Neurosci. 2021 Fall;33(4):314-320. doi: 10.1176/appi.neuropsych.20080205. Epub 2021 Jul 2.
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The structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson's disease.丘脑底核深部脑刺激的结构连接与帕金森病的冲动性有关。
Brain. 2020 Jul 1;143(7):2235-2254. doi: 10.1093/brain/awaa148.
7
Evaluation of methodologies for computing the deep brain stimulation volume of tissue activated.组织激活的深部脑刺激体积计算方法的评估。
J Neural Eng. 2019 Oct 29;16(6):066024. doi: 10.1088/1741-2552/ab3c95.
8
Turning on the Left Side Electrode Changed Depressive State to Manic State in a Parkinson's Disease Patient Who Received Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Case Report.在一名接受双侧丘脑底核深部脑刺激的帕金森病患者中，开启左侧电极使抑郁状态转变为躁狂状态：一例报告
Clin Psychopharmacol Neurosci. 2018 Nov 30;16(4):494-496. doi: 10.9758/cpn.2018.16.4.494.
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