Xie Jianlong, Ou Yongfang, Fu Qiujuan, Ye Zhirong, Chen Yonghua, Yang Ziyi, Lin Liyao, Wu Qin, Wu Dong, Gan Rijian, Wang Junfeng, Luo Qinhui, Zeng Kaiqi, Miao Huilai
Department of Thoracic Surgery, Affiliated Hospital of Guangdong Medical University Zhanjiang 524000, Guangdong, China.
Pathological Diagnosis and Research Center, Affiliated Hospital of Guangdong Medical University Zhanjiang 524000, Guangdong, China.
Am J Cancer Res. 2024 Jun 15;14(6):2755-2769. doi: 10.62347/YLTR8866. eCollection 2024.
As numerous countries around the world have entered an aging society currently, understanding the impact of aging on human health becomes critically important. Notably, aging is associated with increased prevalence of age-related diseases, with the lungs being particularly susceptible. Aging contributes to a decline in lung function, including respiratory disorders, inflammation, and oxidative stress. Therefore, it is a very important to identify and develop active substances that can mitigate lung cell aging. In current study, we evaluated the impact of Taraxasterol on lung cell senescence, showing that Taraxasterol can alleviate lung cell senescence, as evidenced by reductions in senescence-related marker molecules, including p16 and p21. Additionally, Taraxasterol was found to ameliorate inflammation and oxidative stress in lung cells. Further mechanistic studies indicated that Taraxasterol exerts anti-aging effects through the PGC1α/NRF1 signaling pathway in lung cell models. Since aging is also closely related to lung cancer, we also explored the potential anti-tumor effect of taraxasterol. Utilizing non-small cell lung cancer cells (NSCLC) as a model, we systematically study the anti-tumor effect of Taraxasterol both in vivo and in vitro. Our findings suggest that Taraxasterol exhibited anti-cancer effect through EGFR-mediated signaling. Taken together, Taraxasterol shows dual biological activities, offering promising anti-aging and anti-lung cancer benefits.
当前，随着世界上众多国家进入老龄化社会，了解衰老对人类健康的影响变得至关重要。值得注意的是，衰老与年龄相关疾病的患病率增加有关，肺部尤其易感。衰老会导致肺功能下降，包括呼吸系统疾病、炎症和氧化应激。因此，识别和开发能够减轻肺细胞衰老的活性物质非常重要。在本研究中，我们评估了蒲公英甾醇对肺细胞衰老的影响，结果表明蒲公英甾醇可以减轻肺细胞衰老，这可通过衰老相关标记分子（包括p16和p21）的减少得到证明。此外，还发现蒲公英甾醇可改善肺细胞中的炎症和氧化应激。进一步的机制研究表明，在肺细胞模型中，蒲公英甾醇通过PGC1α/NRF1信号通路发挥抗衰老作用。由于衰老也与肺癌密切相关，我们还探索了蒲公英甾醇的潜在抗肿瘤作用。以非小细胞肺癌细胞（NSCLC）为模型，我们系统地研究了蒲公英甾醇在体内和体外的抗肿瘤作用。我们的研究结果表明，蒲公英甾醇通过EGFR介导的信号通路发挥抗癌作用。综上所述，蒲公英甾醇具有双重生物学活性，具有有前景的抗衰老和抗肺癌益处。
