Gravandi Mohammad Mehdi, Hosseini Seyede Zahra, Alavi Seyede Darya, Noori Tayebeh, Sureda Antoni, Amirian Roshanak, Farzaei Mohammad Hosein, Shirooie Samira
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Iran J Pharm Res. 2024 Jun 22;23(1):e142203. doi: 10.5812/ijpr-142203. eCollection 2024 Jan-Dec.
Alzheimer's disease (AD) is a neurodegenerative condition characterized by progressive cognitive deterioration, including deficits in memory and other cognitive functions. Oxidative stress and free radical damage play significant roles in its pathogenesis. This study aimed to investigate the potential anti-inflammatory and neuroprotective effects of gum (administered at doses of 50 and 100 mg/kg for 14 days) in a rat model of AD induced by aluminum chloride (AlCl). Behavioral changes were assessed using open field, passive avoidance, and elevated plus maze tests. Additionally, nitrite levels, nuclear factor-kappa B (NF-κB), brain-derived neurotrophic factor (BDNF), and immunostaining were evaluated. Administration of gum significantly increased step-through latency in the passive avoidance test (P < 0.01 and P < 0.001), enhanced mobility in the open field test (P < 0.01 and P < 0.001), and reduced anxiety-like behaviors in the elevated plus maze (P < 0.001) compared to the AlCl group. Treatment with the gum partially normalized the elevated levels of NF-κB and the decreased levels of BDNF caused by AlCl exposure. Our findings suggest that gum administration may alleviate oxidative stress, neuroinflammation, and cognitive impairment in AD rats.
阿尔茨海默病（AD）是一种神经退行性疾病，其特征为进行性认知功能衰退，包括记忆和其他认知功能缺陷。氧化应激和自由基损伤在其发病机制中起重要作用。本研究旨在探讨[某种胶]（以50和100毫克/千克的剂量给药14天）在氯化铝（AlCl）诱导的AD大鼠模型中的潜在抗炎和神经保护作用。使用旷场试验、被动回避试验和高架十字迷宫试验评估行为变化。此外，还评估了亚硝酸盐水平、核因子-κB（NF-κB）、脑源性神经营养因子（BDNF）和免疫染色。与AlCl组相比，给予[某种胶]显著增加了被动回避试验中的穿通潜伏期（P < 0.01和P < 0.001），增强了旷场试验中的活动能力（P < 0.01和P < 0.001），并减少了高架十字迷宫中的焦虑样行为（P < 0.001）。用[某种胶]治疗部分使由AlCl暴露引起的NF-κB水平升高和BDNF水平降低恢复正常。我们的研究结果表明，给予[某种胶]可能减轻AD大鼠的氧化应激、神经炎症和认知障碍。
