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非糖尿病患者中作为新冠感染后表现的上颌毛霉病性骨坏死:两例报告

Maxillary Mucormycotic Osteonecrosis as a Manifestation of Post-COVID-19 Infection in Non-diabetic Patients: Report of Two Cases.

作者信息

Paavai Thamizhanambi Tamizh, Vasanthi V, Rameshkumar Annasamy, Rajkumar Krishnan, Krishnakumar Raja V B, Muthusubramanian Veerabahu

机构信息

Department of Oral Pathology and Microbiology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.

Department of Oral and Maxillofacial Surgery, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.

出版信息

J Microsc Ultrastruct. 2023 Nov 2;12(2):99-103. doi: 10.4103/jmau.jmau_81_23. eCollection 2024 Apr-Jun.

DOI:10.4103/jmau.jmau_81_23
PMID:39006044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11245128/
Abstract

Mucormycosis is a rare, opportunistic fungal infection prevalent in the elderly, especially in patients with uncontrolled diabetes or a compromised immune system. However, the outbreak of the pandemic declared by the World Health Organization in late 2019 increased the incidence of mucormycosis cases in COVID-19 patients due to increased steroid usage that resulted in an immunocompromised state. The current report presents two cases of oral mucormycotic osteomyelitis in patients who developed diabetes post-COVID infection, along with a review and relevant literature.

摘要

毛霉菌病是一种罕见的机会性真菌感染,在老年人中较为普遍,尤其是在糖尿病控制不佳或免疫系统受损的患者中。然而,世界卫生组织于2019年末宣布的大流行爆发,由于类固醇使用增加导致免疫功能低下状态,增加了COVID-19患者中毛霉菌病病例的发病率。本报告介绍了两例COVID感染后患上糖尿病的患者发生口腔毛霉菌性骨髓炎的病例,并对相关文献进行了综述。

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本文引用的文献

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Post-COVID-19 maxillary osteonecrosis and floating maxillary teeth due to mucormycosis in two uncontrolled diabetic patients.两名未控制的糖尿病患者因毛霉菌病导致新冠病毒感染后上颌骨坏死和上颌牙松动
Clin Case Rep. 2022 Mar 10;10(3):e05502. doi: 10.1002/ccr3.5502. eCollection 2022 Mar.
2
Mucormycosis Amid COVID-19 Crisis: Pathogenesis, Diagnosis, and Novel Treatment Strategies to Combat the Spread.COVID-19危机中的毛霉病:发病机制、诊断及对抗传播的新型治疗策略
Front Microbiol. 2022 Jan 4;12:794176. doi: 10.3389/fmicb.2021.794176. eCollection 2021.
3
Maxillary Mucormycosis Osteomyelitis in Post COVID-19 Patients: A Series of Fourteen Cases.
新冠后患者的上颌毛霉菌病性骨髓炎:14例病例系列
Diagnostics (Basel). 2021 Nov 5;11(11):2050. doi: 10.3390/diagnostics11112050.
4
COVID-19 associated mucormycosis (CAM) in India: a formidable challenge.印度 COVID-19 相关毛霉菌病(CAM):一个严峻的挑战。
Br J Oral Maxillofac Surg. 2021 Nov;59(9):1095-1098. doi: 10.1016/j.bjoms.2021.06.013. Epub 2021 Jun 29.
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A case report of rhino-facial mucormycosis in a non-diabetic patient with COVID-19: a systematic review of literature and current update.非糖尿病合并 COVID-19 患者的鼻面部毛霉菌病病例报告:文献系统评价及最新进展
BMC Infect Dis. 2021 Sep 3;21(1):906. doi: 10.1186/s12879-021-06625-3.
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Post-Covid alliance-mucormycosis, a fatal sequel to the pandemic in India.新冠后联盟-毛霉菌病,印度疫情的致命后遗症。
Saudi J Biol Sci. 2021 Nov;28(11):6461-6464. doi: 10.1016/j.sjbs.2021.07.004. Epub 2021 Jul 10.
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Current Understanding in the Pathophysiology of SARS-CoV-2-Associated Rhino-Orbito-Cerebral Mucormycosis: A Comprehensive Review.严重急性呼吸综合征冠状病毒2相关鼻眶脑毛霉菌病病理生理学的当前认识:一项综述
J Maxillofac Oral Surg. 2021 Sep;20(3):373-380. doi: 10.1007/s12663-021-01604-2. Epub 2021 Jun 16.
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