Lussier B, Vranic M, Gauthier C, Hetenyi G
Metabolism. 1985 Oct;34(10):906-11. doi: 10.1016/0026-0495(85)90136-2.
In nonanesthetized dogs treated with 3 mg/kg . d methyl-prednisolone (MP) for four days the infusion of phlorizin decreases plasma glucose only transiently. The basal level is restored by an increase in hepatic glucose production. The concentration of plasma glucagon (IRG) is raised only about 26%, compared to the increase of 150% observed previously in untreated dogs. In insulin-induced hypoglycemia, hepatic glucose production increases and both the concentrations of epinephrine and IRG in the plasma are elevated significantly. Recovery from hypoglycemia after the cessation of the infusion is significantly faster than observed previously in normal dogs. The following conclusions were reached: In MP-treated dogs during the infusion of phlorizin (in nonhypoglycemic glucoregulation) normoglycemia is restored faster, and by a much smaller increment in plasma glucagon concentration than previously observed in normal dogs. Regulation in overt hypoglycemia too operates more efficiently. In nonhypoglycemic glucoregulation a small change in plasma glucose concentration appears to be the primary stimulus that releases glucagon to the extent necessary to achieve the appropriate increase in hepatic glucose production in a given endocrine milieu.
在以3毫克/千克·天的甲基泼尼松龙（MP）治疗4天的未麻醉犬中，输注根皮苷仅使血浆葡萄糖短暂降低。基础水平通过肝葡萄糖生成增加得以恢复。与之前在未治疗犬中观察到的150%的增加相比，血浆胰高血糖素（免疫反应性胰高血糖素，IRG）浓度仅升高约26%。在胰岛素诱导的低血糖症中，肝葡萄糖生成增加，血浆中肾上腺素和IRG的浓度均显著升高。输注停止后从低血糖症中恢复的速度明显快于之前在正常犬中观察到的情况。得出以下结论：在MP治疗的犬中输注根皮苷期间（在非低血糖性葡萄糖调节中），正常血糖恢复得更快，且血浆胰高血糖素浓度的增量比之前在正常犬中观察到的小得多。明显低血糖时的调节也更有效。在非低血糖性葡萄糖调节中，血浆葡萄糖浓度的微小变化似乎是主要刺激因素，它能在给定的内分泌环境中释放出足以使肝葡萄糖生成适当增加所需程度的胰高血糖素。
