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青蒿素诱导的胆汁淤积性肝损伤和肝内胆管减少症。

Artemisinin-induced cholestatic liver injury and intrahepatic ductopenia.

作者信息

Thio Joel, Haig Adam, Swe Ei Phyu Phyu, Nguyen Paul, Tran Kayla, Kasi Madhavi

机构信息

Department of Gastroenterology, The Prince Charles Hospital, 627 Rode Road, Brisbane, Queensland 4032, Australia.

Faculty of Medicine, University of Queensland, Mayne Medical School, 20 Weightman St, Brisbane, Queensland 4006, Australia.

出版信息

Oxf Med Case Reports. 2024 Jul 13;2024(7):omae070. doi: 10.1093/omcr/omae070. eCollection 2024 Jul.

DOI:10.1093/omcr/omae070
PMID:39006507
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11246553/
Abstract

Artemisinin, an ancient Chinese herbal remedy known colloquially as "Qinghao", is now used as treatment for malaria as recommended by the World Health Organisation. There have been few reports of artemisinin-induced liver injury. Most of these instances of hepatotoxicity are reportedly due to prolonged use of herbal remedies containing artemisinin. To our knowledge, we report the first case of intrahepatic ductopenia in a patient with cholestatic liver injury after artemisinin use.

摘要

青蒿素，一种俗称“青蒿”的古老的中国草药疗法，现在被世界卫生组织推荐用于治疗疟疾。关于青蒿素引起肝损伤的报道很少。据报道，这些肝毒性病例大多是由于长期使用含青蒿素的草药疗法所致。据我们所知，我们报告了首例使用青蒿素后出现胆汁淤积性肝损伤并伴有肝内胆管减少的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbd/11246553/231e102e8b29/omae070f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbd/11246553/a10f7319f91f/omae070f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbd/11246553/111b8adfd06e/omae070f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbd/11246553/231e102e8b29/omae070f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbd/11246553/a10f7319f91f/omae070f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbd/11246553/111b8adfd06e/omae070f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbd/11246553/231e102e8b29/omae070f3.jpg

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本文引用的文献

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Editorial: Artemisinin-From Traditional Chinese Medicine to Artemisinin Combination Therapies; Four Decades of Research on the Biochemistry, Physiology, and Breeding of .社论：青蒿素——从传统中药到青蒿素联合疗法；四十年来关于其生物化学、生理学及育种的研究
Front Plant Sci. 2020 Sep 18;11:594565. doi: 10.3389/fpls.2020.594565. eCollection 2020.
2
Danger of Herbal Tea: A Case of Acute Cholestatic Hepatitis Due to Tea.凉茶的危害：一例因茶导致的急性胆汁淤积性肝炎病例
Front Med (Lausanne). 2019 Oct 11;6:221. doi: 10.3389/fmed.2019.00221. eCollection 2019.
3
Mechanisms of artemisinin resistance in Plasmodium falciparum malaria.
青蒿素抗药性在恶性疟原虫疟疾中的机制。
Curr Opin Pharmacol. 2018 Oct;42:46-54. doi: 10.1016/j.coph.2018.06.003. Epub 2018 Aug 1.
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Cholestatic liver injury secondary to artemisinin.青蒿素继发的胆汁淤积性肝损伤。
Hepatology. 2015 Sep;62(3):973-4. doi: 10.1002/hep.27900. Epub 2015 Jul 22.
5
The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety.草药使用的日益增加：与不良反应相关的问题及安全性监测面临的挑战。
Front Pharmacol. 2014 Jan 10;4:177. doi: 10.3389/fphar.2013.00177.
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Hepatitis temporally associated with an herbal supplement containing artemisinin - Washington, 2008.2008年，华盛顿州，与含青蒿素的草药补充剂存在时间关联的肝炎。
MMWR Morb Mortal Wkly Rep. 2009 Aug 14;58(31):854-6.