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胃癌患者胰岛素样生长因子结合蛋白3及其死亡受体的临床病理相关性

Clinicopathological correlation of insulin-like growth factor binding protein 3 and their death receptor in patients with gastric cancer.

作者信息

Ansari Amir, Gheysarzadeh Ali, Sharifi Ali, Mofid Mohammad Reza

机构信息

Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.

Department of Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

出版信息

Res Pharm Sci. 2024 Feb 6;19(1):42-52. doi: 10.4103/1735-5362.394819. eCollection 2024 Feb.

DOI:10.4103/1735-5362.394819
PMID:39006978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11244704/
Abstract

BACKGROUND AND PURPOSE

The insulin-like growth factor binding protein 3 (IGFBP-3) and its novel death receptor (IGFBP-3R) have been exhibited to have tumor suppressor effects. Despite their prognostic value in some cancers, they have not been elucidated in gastric cancer.

EXPERIMENTAL APPROACH

We collected 68 samples from patients with gastric cancer. IGFBP-3 and IGFBP-3R expression levels were evaluated with quantitative real-time polymerase chain reaction (RT-PCR) and western blotting in patients. The relationship between prognostic factors and IGFBP-3/IGFBP-3R expression was also evaluated.

FINDINGS/RESULTS: Our results showed that IGFBP-3 and IGFBP-3R expression was reduced significantly in tumor tissues. We found that there was an association between the reduction of IGFBP-3 with lymph node metastasis and tumor-node-metastasis (TNM) staging. Besides, IGFBP-3R expression was associated with tumor size, lymph node metastasis, differentiation, and TNM classification. Interestingly, we presented that the downregulation of IGFBP-3R was stage-dependent. In survival analysis, our findings showed that low levels of IGFBP-3R mRNA expression exhibited a close correlation with survival rate.

CONCLUSION AND IMPLICATIONS

The findings of this study showed that the expression levels of IGFBP-3 and IGFBP-3R are valuable prognostic factors. Despite the potential of IGFBP-3, IGFBP-3R plays a significant role as a prognostic factor in gastric cancer. However, these findings need to be developed and confirmed by further studies.

摘要

背景与目的

胰岛素样生长因子结合蛋白3（IGFBP - 3）及其新型死亡受体（IGFBP - 3R）已被证明具有肿瘤抑制作用。尽管它们在某些癌症中具有预后价值，但在胃癌中尚未得到阐明。

实验方法

我们收集了68例胃癌患者的样本。采用定量实时聚合酶链反应（RT - PCR）和蛋白质印迹法评估患者体内IGFBP - 3和IGFBP - 3R的表达水平。还评估了预后因素与IGFBP - 3/IGFBP - 3R表达之间的关系。

研究结果

我们的结果显示，肿瘤组织中IGFBP - 3和IGFBP - 3R的表达显著降低。我们发现IGFBP - 3的降低与淋巴结转移和肿瘤 - 淋巴结 - 转移（TNM）分期之间存在关联。此外，IGFBP - 3R的表达与肿瘤大小、淋巴结转移、分化程度和TNM分类相关。有趣的是，我们发现IGFBP - 3R的下调具有分期依赖性。在生存分析中，我们的研究结果表明，低水平的IGFBP - 3R mRNA表达与生存率密切相关。

结论与意义

本研究结果表明，IGFBP - 3和IGFBP - 3R的表达水平是有价值的预后因素。尽管IGFBP - 3具有潜在作用，但IGFBP - 3R作为胃癌的预后因素发挥着重要作用。然而，这些发现需要进一步研究来拓展和证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9a/11244704/b88748b9d007/RPS-19-42-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9a/11244704/096c22acfa80/RPS-19-42-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9a/11244704/93f4968421ee/RPS-19-42-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9a/11244704/c273a0807480/RPS-19-42-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9a/11244704/b88748b9d007/RPS-19-42-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9a/11244704/096c22acfa80/RPS-19-42-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9a/11244704/ae3a3e3b3018/RPS-19-42-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9a/11244704/93f4968421ee/RPS-19-42-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9a/11244704/c273a0807480/RPS-19-42-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c9a/11244704/b88748b9d007/RPS-19-42-g006.jpg

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本文引用的文献

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The insulin-like growth factor binding protein-3 and its death receptor in pancreatic ductal adenocarcinoma poor prognosis.胰岛素样生长因子结合蛋白-3 及其死亡受体与胰腺导管腺癌不良预后相关。
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