Rubin John E, Ng Vanessa, Chung Justin, Salvatierra Nicolas, Rippon Brady, Khatib Diana, Girardi Natalia I, Pryor Kane O, Weinberg Roniel Y, Jiang Silis, Khairallah Sherif, Mick Stephanie L, Tedore Tiffany R
Department of Anesthesiology, NewYork-Presbyterian/Weill Cornell Medicine, New York, NY, USA.
Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL, USA.
BJA Open. 2024 Jun 20;11:100288. doi: 10.1016/j.bjao.2024.100288. eCollection 2024 Sep.
Sternal pain after cardiac surgery results in considerable discomfort. Single-injection parasternal fascial plane blocks have been shown to reduce pain scores and opioid consumption during the first 24 h after surgery, but the efficacy of continuous infusion has not been evaluated. This retrospective cohort study examined the effect of a continuous infusion of local anaesthetic through parasternal catheters on the integrated Pain Intensity and Opioid Consumption (PIOC) score up to 72 h.
We performed a retrospective analysis of patients undergoing cardiac surgery with median sternotomy at a single academic centre before and after the addition of parasternal nerve catheters to a standard multimodal analgesic protocol. Outcomes included PIOC score, total opioid consumption in oral morphine equivalents, and time-weighted area under the curve pain scores up to 72 h after surgery.
Continuous infusion of ropivacaine 0.1% through parasternal catheters resulted in a significant reduction in PIOC scores at 24 h (-62, 95% confidence interval -108 to -16; <0.01) and 48 h (-50, 95% CI -97 to -2.2; =0.04) compared with no block. A significant reduction in opioid consumption up to 72 h was the primary factor in reduction of PIOC.
This study suggests that continuous infusion of local anaesthetic through parasternal catheters may be a useful addition to a multimodal analgesic protocol in patients undergoing cardiac surgery with sternotomy. Further prospective study is warranted to determine the full benefits of continuous infusion compared with single injection or no block.
心脏手术后的胸骨疼痛会导致相当大的不适。单次注射胸骨旁筋膜平面阻滞已被证明可降低术后24小时内的疼痛评分和阿片类药物消耗量,但持续输注的疗效尚未得到评估。这项回顾性队列研究考察了通过胸骨旁导管持续输注局部麻醉药对长达72小时的综合疼痛强度和阿片类药物消耗量(PIOC)评分的影响。
我们对在单一学术中心接受正中胸骨切开术的心脏手术患者进行了回顾性分析,这些患者在标准多模式镇痛方案中添加胸骨旁神经导管前后。结果包括PIOC评分、以口服吗啡当量计算的总阿片类药物消耗量,以及术后长达72小时的曲线下时间加权疼痛评分。
与未进行阻滞相比,通过胸骨旁导管持续输注0.1%罗哌卡因在24小时(-62,95%置信区间-108至-16;<0.01)和48小时(-50,95%CI-97至-2.2;=0.04)时导致PIOC评分显著降低。长达72小时的阿片类药物消耗量显著减少是PIOC降低的主要因素。
本研究表明,对于接受胸骨切开术的心脏手术患者,通过胸骨旁导管持续输注局部麻醉药可能是多模式镇痛方案的有益补充。有必要进行进一步的前瞻性研究,以确定持续输注与单次注射或不进行阻滞相比的全部益处。