Orofacial Pain and Jaw Function, Malmö University, Malmö, Sweden.
Centre for Oral Rehabilitation, in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
J Oral Rehabil. 2024 Oct;51(10):2082-2092. doi: 10.1111/joor.13806. Epub 2024 Jul 15.
Juvenile idiopathic arthritis (JIA) often affects the temporomandibular joint (TMJ) caused by an abnormal immune system that includes overactive inflammatory processes. Salivary biomarkers may be a powerful tool that can help establishing diagnosis, prognosis and monitor disease progress.
The objective was to investigate biomarkers in parotid saliva and blood plasma in relation to temporomandibular joint (TMJ) magnetic resonance imaging (MRI) findings in patients with JIA and healthy individuals.
Forty-five children aged 6 to 16 years with JIA and 16 healthy age- and sex-matched controls were included. Unstimulated parotid saliva samples and venous blood were collected. Biochemical analyses were performed for the cytokine biomarkers. The participants underwent MR imaging of the TMJs, where changes in the inflammatory and the damage domains were assessed.
In the JIA patients, lower concentrations of IL-6R and gp130 were found in parotid saliva than in plasma. Higher concentrations of IL-6 were found in parotid saliva than in plasma. IL-6, IL-6R and gp130 in parotid saliva explained the presence of bone marrow oedema and effusion in the JIA patients.
This study suggests that the IL-6 family in parotid saliva is associated with TMJ bone marrow oedema and effusion in patients with JIA, suggesting that IL-6 has promising properties as a parotid saliva biomarker for TMJ inflammatory activity.
幼年特发性关节炎 (JIA) 常影响颞下颌关节 (TMJ)，其病因是异常的免疫系统，包括过度活跃的炎症过程。唾液生物标志物可能是一种强大的工具，可以帮助建立诊断、预后和监测疾病进展。
本研究旨在探讨 JIA 患者和健康对照者的腮腺唾液和血浆生物标志物与 TMJ 磁共振成像 (MRI) 结果的关系。
纳入 45 名年龄在 6 至 16 岁的 JIA 患儿和 16 名年龄和性别匹配的健康对照者。采集非刺激性腮腺唾液样本和静脉血。对细胞因子生物标志物进行生化分析。对 TMJ 进行 MRI 检查，评估炎症和损伤两个方面的变化。
JIA 患者的腮腺唾液中 IL-6R 和 gp130 的浓度低于血浆，而 IL-6 的浓度则高于血浆。腮腺唾液中的 IL-6、IL-6R 和 gp130 可解释 JIA 患者骨髓水肿和关节腔积液的存在。
本研究表明，JIA 患者 TMJ 骨髓水肿和关节腔积液与腮腺唾液中的 IL-6 家族有关，提示 IL-6 作为 TMJ 炎症活动的腮腺唾液生物标志物具有良好的应用前景。
