Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India.
J Neural Transm (Vienna). 2024 Sep;131(9):1025-1037. doi: 10.1007/s00702-024-02803-0. Epub 2024 Jul 15.
Psychiatric disorders such as Bipolar disorder, Anxiety, Major depressive disorder, Schizophrenia, Attention-deficit/hyperactivity disorder, as well as neurological disorders such as Migraine, are linked by the evidence of altered calcium homeostasis. The disturbance of intra-cellular calcium homeostasis disrupts the activity of numerous ion channels including transient receptor potential (TRP) channels. TRP channel families comprise non-selective calcium-permeable channels that have been implicated in variety of physiological processes in the brain, as well as in the pathogenesis of psychiatric disorders. Through a comprehensive review of current research and experimentation, this investigation elucidates the role of TRP channels in psychiatric disorders. Furthermore, this review discusses about the exploration of epigenetics and TRP channels in psychiatric disorders.
精神障碍，如双相情感障碍、焦虑症、重度抑郁症、精神分裂症、注意缺陷/多动障碍，以及神经障碍，如偏头痛，都与钙稳态改变的证据有关。细胞内钙稳态的紊乱会破坏包括瞬时受体电位（TRP）通道在内的许多离子通道的活性。TRP 通道家族包含非选择性钙通透性通道，这些通道与大脑中的多种生理过程以及精神障碍的发病机制有关。通过对当前研究和实验的全面回顾，本研究阐明了 TRP 通道在精神障碍中的作用。此外，本综述还讨论了表观遗传学和 TRP 通道在精神障碍中的探索。
