Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, China.
Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, China.
Scand J Immunol. 2024 Mar;99(3):e13357. doi: 10.1111/sji.13357. Epub 2024 Jan 19.
Group 2 innate lymphoid cells (ILC2s) are a type of innate immune cells that produce a large amount of IL-5 and IL-13 and two cytokines that are crucial for various processes such as allergic airway inflammation, tissue repair and tissue homeostasis. It is known that damaged epithelial-derived alarmins, such as IL-33, IL-25 and thymic stromal lymphopoietin (TSLP), are the predominant ILC2 activators that mediate the production of type 2 cytokines. In recent years, abundant studies have found that many factors can regulate ILC2 development and function. Hormones synthesized by the body's endocrine glands or cells play an important role in immune response. Notably, ILC2s express hormone receptors and their proliferation and function can be modulated by multiple hormones during allergic airway inflammation. Here, we summarize the effects of multiple hormones on ILC2-driven allergic airway inflammation and discuss the underlying mechanisms and potential therapeutic significance.
2 型固有淋巴细胞 (ILC2) 是一种先天免疫细胞，可大量产生 IL-5 和 IL-13 以及两种细胞因子，这些细胞因子对于过敏气道炎症、组织修复和组织稳态等各种过程至关重要。已知受损的上皮衍生警报素，如 IL-33、IL-25 和胸腺基质淋巴生成素 (TSLP)，是主要的 ILC2 激活剂，介导 2 型细胞因子的产生。近年来，大量研究发现许多因素可以调节 ILC2 的发育和功能。由人体内分泌腺或细胞合成的激素在免疫反应中起着重要作用。值得注意的是，ILC2 表达激素受体，其增殖和功能可在过敏气道炎症期间被多种激素调节。在这里，我们总结了多种激素对 ILC2 驱动的过敏气道炎症的影响，并讨论了潜在的机制和潜在的治疗意义。
