Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang, 421001, Hunan, China.
Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, 421001, Hunan, China.
Cell Mol Life Sci. 2019 Nov;76(22):4503-4510. doi: 10.1007/s00018-019-03228-9. Epub 2019 Jul 16.
Group 2 innate lymphoid cells (ILC2s) are a subset of innate immune cells that do not express antigen receptors. ILC2-mediated type 2 responses, which are mainly characterized by the production of interleukin (IL)-5 and IL-13, play key roles in inducing inflammation, protecting against infection, and maintaining tissue homeostasis. Although recent years have largely enhanced our understanding of the transcriptional networks and soluble mediators that regulate ILC2 development or function, emerging evidence suggests that ILC2s express a variety of cell-surface molecules and interact with themselves or other immune cells. These cell-cell interactions are essential in the modulation of ILC2 number and their type 2 cytokine production during ILC2-driven allergic inflammation. In this review, we summarize the extensive array of cell-surface molecules on ILC2s that mediate cell-cell interactions and their role in regulating ILC2 generation or function in the context of ILC2-induced allergic inflammation.
2 型固有淋巴细胞 (ILC2s) 是先天免疫细胞的一个亚群，它们不表达抗原受体。ILC2 介导的 2 型反应主要表现为白细胞介素 (IL)-5 和 IL-13 的产生，在诱导炎症、抵御感染和维持组织内稳态方面发挥着关键作用。尽管近年来在很大程度上增强了我们对调节 ILC2 发育或功能的转录网络和可溶性介质的理解，但新出现的证据表明，ILC2 表达多种细胞表面分子，并与自身或其他免疫细胞相互作用。这些细胞-细胞相互作用对于调节 ILC2 的数量及其在 ILC2 驱动的过敏炎症期间产生 2 型细胞因子至关重要。在这篇综述中，我们总结了 ILC2 上介导细胞-细胞相互作用的广泛的细胞表面分子及其在调节 ILC2 生成或功能方面的作用，特别是在 ILC2 诱导的过敏炎症的背景下。
