喹啉酸诱导未麻醉猫的海马癫痫发作。
Quisqualic acid-induced hippocampal seizures in unanesthetized cats.
作者信息
Fukuda H, Tanaka T, Kaijima M, Nakai H, Yonemasu Y
出版信息
Neurosci Lett. 1985 Aug 16;59(1):53-9. doi: 10.1016/0304-3940(85)90214-9.
An intrahippocampal injection of quisqualic acid (QA) was made in chronically implanted freely moving unanesthetized cats and electrographic and clinical observations were made. Fourteen to 40 micrograms of QA injection resulted in a mild limbic seizure within 24 h after QA injection. Some cats demonstrated a pure hippocampal seizure on an electroencephalogram. Electrographic changes and clinical manifestations were less prominent as compared with those of kainic acid. Histopathological examination showed a selective loss of pyramidal cell layer of the CA3 portion in the injected side of the dorsal hippocampus. A mild but constant epileptogenic potency of QA has an advantage for an experimental model of temporal lobe epilepsy in man.
对长期植入电极且自由活动、未麻醉的猫进行海马内注射喹啉酸（QA），并进行脑电图和临床观察。注射14至40微克QA后，在24小时内引发轻度边缘系统发作。部分猫在脑电图上表现为单纯的海马发作。与 kainic 酸相比，脑电图变化和临床表现不那么突出。组织病理学检查显示，背侧海马注射侧CA3部分的锥体细胞层有选择性丢失。QA 具有轻度但持续的致癫痫效力，这对人类颞叶癫痫的实验模型来说是一个优势。
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