Laboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Cascavel, Brazil.
Parasite Immunol. 2024 Jul;46(7):e13057. doi: 10.1111/pim.13057.
Chagas disease is a parasitic disease caused by the protozoan Trypanosoma cruzi with an acute, detectable blood parasites phase and a chronic phase, in which the parasitemia is not observable, but cardiac and gastrointestinal consequences are possible. Mice are the principal host used in experimental Chagas disease but reproduce the human infection depending on the animal and parasite strain, besides dose and route of administration. Lipidic mediators are tremendously involved in the pathogenesis of T. cruzi infection, meaning the prostaglandins and thromboxane, which participate in the immunosuppression characteristic of the acute phase. Thus, the eicosanoids inhibition caused by the nonsteroidal anti-inflammatory drugs (NSAIDs) alters the dynamic of the disease in the experimental models, both in vitro and in vivo, which can explain the participation of the different mediators in infection. However, marked differences are founded in the various NSAIDs existing because of the varied routes blocked by the drugs. So, knowing the results in the experimental models of Chagas disease with or without the NSAIDs helps comprehend the pathogenesis of this infection, which still needs a better understanding.
恰加斯病是一种寄生虫病，由原生动物克氏锥虫引起，具有急性、可检测到血液寄生虫阶段和慢性阶段，在慢性阶段，寄生虫血症不可见，但可能存在心脏和胃肠道后果。小鼠是实验性恰加斯病的主要宿主，但根据动物和寄生虫株的不同，以及剂量和给药途径的不同，可能会再现人类感染。脂类介质在克氏锥虫感染的发病机制中起着重要作用，即前列腺素和血栓素，它们参与急性阶段的免疫抑制。因此，非甾体抗炎药（NSAIDs）引起的类二十烷酸抑制改变了实验模型中疾病的动态，无论是在体外还是体内，这可以解释不同介质在感染中的参与。然而，由于药物阻断的途径不同，存在的各种 NSAIDs 之间存在明显差异。因此，了解有或没有 NSAIDs 的恰加斯病实验模型的结果有助于理解这种感染的发病机制，这种感染仍然需要更好的理解。
