Department of Ophthalmology, The First People's Hospital of Xuzhou, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR China.
Department of Ophthalmology, The First People's Hospital of Xuzhou, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, PR China; First School of Clinical Medicine of Xuzhou Medical University, Xuzhou, Jiangsu, PR China.
Photodiagnosis Photodyn Ther. 2024 Oct;49:104267. doi: 10.1016/j.pdpdt.2024.104267. Epub 2024 Jul 14.
To evaluate the effectiveness of low-level red light (LRL) in controlling the progression of myopia in children and adolescents.
A randomized controlled trial was conducted from March 2022 to June 2022 at the Xuzhou First People's Hospital. A total of 73 children and adolescents with myopia, between the ages of 6 and 14, and meeting the inclusion criteria, were randomly divided into two groups. The experimental group wore single vision spectacles with LRL intervention, while the control group wore single vision spectacles alone. Spherical equivalent refraction (SER), axial length (AL), subfoveal choroidal thickness (SFCT), and best-corrected visual acuity (BCVA) were measured for the participants. Data analysis was performed using chi-square test, independent samples t-test, and Mann-Whitney U test. To compare the changes in SER and AL between groups, we utilized the Generalized Estimating Equations (GEE) model.
The experimental group was composed of 36 individuals, while the control group had 37. The mean age of the participants was 8.9 ± 2.0 years. No statistically significant distinctions in SER, AL and SFCT were observed between the two groups at baseline (P > 0.05). After 6 months of intervention, the experimental group's increase in SER (-0.01D; 95 % CI: -0.09, 0.06) was higher than that of the control group (-0.41D; 95 % CI: -0.51, -0.32), with a significance level of P < 0.001. Furthermore, the changes over time revealed significant differences between the two groups (Wald χ2: 31.576, P < 0.001). The experimental group's AL increase (-0.02 mm; 95 % CI: -0.07, 0.03) was less than the control group's (0.22 mm; 95 % CI: 0.19, 0.25) (P < 0.001), with a significant difference over time between them (wald χ2: 62.305, P < 0.001). SFCT change after 6 months in the experimental group was significantly greater (29.19 μm; 95 % CI: 18.48, 39.91) compared to that of the control group (-6.59 μm; 95 % CI: -14.28, 1.09) (P < 0.001). No adverse events were observed, and there was no evidence of fundus structural damage on OCT imaging.
The findings suggest that low-level red light can effectively control myopia progression in children and adolescents within 6 months. No adverse reactions were observed.
评估低水平红光（LRL）控制儿童和青少年近视进展的有效性。
这是一项 2022 年 3 月至 6 月在徐州市第一人民医院进行的随机对照试验。共纳入 73 名年龄在 6 至 14 岁之间、符合纳入标准的近视儿童和青少年，将其随机分为两组。实验组佩戴具有 LRL 干预功能的单焦眼镜，对照组仅佩戴单焦眼镜。对参与者进行球镜等效屈光度（SER）、眼轴长度（AL）、中心凹下脉络膜厚度（SFCT）和最佳矫正视力（BCVA）的测量。使用卡方检验、独立样本 t 检验和曼-惠特尼 U 检验进行数据分析。为比较两组 SER 和 AL 的变化，我们使用了广义估计方程（GEE）模型。
实验组有 36 人，对照组有 37 人。参与者的平均年龄为 8.9 ± 2.0 岁。两组在基线时的 SER、AL 和 SFCT 均无统计学差异（P > 0.05）。干预 6 个月后，实验组的 SER 增加（-0.01D；95 % CI：-0.09，0.06）高于对照组（-0.41D；95 % CI：-0.51，-0.32），差异具有统计学意义（P < 0.001）。此外，两组之间的时间变化差异具有统计学意义（Wald χ2：31.576，P < 0.001）。实验组的 AL 增加（-0.02 mm；95 % CI：-0.07，0.03）小于对照组（0.22 mm；95 % CI：0.19，0.25）（P < 0.001），两组之间的差异也具有统计学意义（wald χ2：62.305，P < 0.001）。实验组在 6 个月时的 SFCT 变化显著大于对照组（29.19 μm；95 % CI：18.48，39.91）（P < 0.001）。未观察到不良事件，OCT 成像也未发现眼底结构损伤的证据。
低水平红光可在 6 个月内有效控制儿童和青少年近视的进展，未见不良反应。
