Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Mol Syst Biol. 2024 Aug;20(8):845-847. doi: 10.1038/s44320-024-00056-3. Epub 2024 Jul 15.
In a variety of infections, bacteria form multicellular communities which contribute to virulence and antibiotic tolerance. The molecular biology of such communities is actively studied, but our understanding of them remains incomplete. In this issue, Şimşek et al have developed and experimentally validated a dynamic model for community formation and revealed general insights into bacterial collective survival during antibiotic exposure.
在各种感染中,细菌会形成有助于毒力和抗生素耐药性的多细胞群落。这些群落的分子生物学正在被积极研究,但我们对它们的理解仍然不完整。在本期中,Şimşek 等人开发并实验验证了一种用于群落形成的动态模型,并揭示了在抗生素暴露期间细菌集体存活的一般见解。