一项针对多发性骨髓瘤患者的多学科小组式生存干预:一项可行性研究。
A multidisciplinary group-based survivorship intervention for those living with multiple myeloma: a feasibility study.
作者信息
Eilert Nora, Murphy Norma-Jean, Cummins Hannah, Houlihan Emma, Krawczyk Janusz
机构信息
Cancer Care West, 72 Seamus Quirke Rd, Galway, Ireland.
Galway University Hospital, Newcastle Rd, Galway, Ireland.
出版信息
Pilot Feasibility Stud. 2024 Jul 15;10(1):100. doi: 10.1186/s40814-024-01524-1.
BACKGROUND
While multiple myeloma continues to be an incurable cancer, advances in its understanding and management have led to significantly improved survival rates. Survivorship interventions for those living with multiple myeloma remain scarce, despite mounting evidence for multiple unmet support needs among multiple myeloma survivors. The current study aimed to evaluate the feasibility and preliminary effectiveness of a novel multidisciplinary group-based multiple myeloma survivorship intervention.
METHODS
A mixed-method, repeated measures feasibility study was conducted within a routine cancer support service. Seven participants, aged over 18, who had a multiple myeloma diagnosis and were clinically assessed as suitable for the intervention by their haemato-oncologist, attended online for six weekly group sessions of physical exercise and self-management input, completing qualitative, physical and self-report measures at baseline, post-intervention and follow-up.
RESULTS
The intervention was deemed overall feasible, with relatively high uptake, participants describing it as largely acceptable and appropriate and providing recommendations for feasibility-enhancing intervention refinements. Findings regarding the preliminary effectiveness of the intervention were mixed. While qualitative analyses stressed the benefits of the intervention (e.g. peer support, connectedness, improved well-being) and large effect sizes were observed for most physical outcomes, no improvements in self-reported outcomes (i.e. quality of life, fatigue) were reported.
CONCLUSIONS
This study represents the first investigation of a promising novel survivorship intervention for those living with multiple myeloma, highlighting the importance of peer support in particular, on which future clinical trials, aiming to establish the intervention's effectiveness for routine care, will be able to build.
背景
虽然多发性骨髓瘤仍然是一种无法治愈的癌症,但其在认知和管理方面的进展已使生存率显著提高。尽管有越来越多的证据表明多发性骨髓瘤幸存者存在多种未得到满足的支持需求,但针对这些幸存者的生存干预措施仍然很少。本研究旨在评估一种新型的多学科小组多发性骨髓瘤生存干预措施的可行性和初步效果。
方法
在一项常规癌症支持服务中进行了一项混合方法、重复测量的可行性研究。七名年龄超过18岁、被诊断为多发性骨髓瘤且血液肿瘤学家临床评估适合该干预措施的参与者,参加了为期六周的在线小组课程,内容包括体育锻炼和自我管理指导,并在基线、干预后和随访时完成定性、身体和自我报告测量。
结果
该干预措施总体上被认为是可行的,参与率相对较高,参与者将其描述为在很大程度上是可接受和适当的,并为提高可行性的干预改进提供了建议。关于干预措施初步效果的研究结果喜忧参半。虽然定性分析强调了干预措施的益处(如同伴支持、联系感、幸福感提高),并且在大多数身体指标上观察到了较大的效应量,但自我报告指标(即生活质量、疲劳)没有改善。
结论
本研究首次对一种有前景的新型多发性骨髓瘤幸存者生存干预措施进行了调查,突出了同伴支持的重要性,尤其是在未来旨在确定该干预措施在常规护理中的有效性的临床试验中可以在此基础上开展研究。