Zhang Simeng, Liu Jian, Qu Wenran, Wei Huimin, Wang Jiurui, Wang Zhiwei, Yan Zeping, Liu Mengqi, Wang Xiaoli, Luan Xiaorong
J Cardiovasc Nurs. 2025;40(2):114-123. doi: 10.1097/JCN.0000000000001124. Epub 2024 Jul 16.
Older patients with chronic heart failure (CHF) are prone to insomnia. Studies have shown that insomnia affects the onset of cognitive frailty and is also strongly associated with depressive symptoms and social support. However, information on how these factors interact to influence cognitive frailty remains underexplored.
Our aim in this study was to explore the multiple mediating roles of depressive symptoms and social support in the relationship between insomnia and cognitive frailty.
We recruited 300 hospitalized older patients with CHF to participate in this study. The participants completed the Athens Insomnia Scale, Geriatric Depression Scale, Montreal Cognitive Assessment, FRAIL Scale, and Social Support Rating Scale. The mediation hypothesis was tested using a multiple mediation model and bootstrapping method.
In this study, 44% of the patients experienced insomnia, and 51.3% were in a state of cognitive frailty. Our main findings suggest that insomnia has an indirect effect on cognitive frailty through 2 pathways: the multiple mediating effects of depressive symptoms and social support, and a single mediating effect of depressive symptoms. The direct effect of insomnia on cognitive frailty is also significant.
Older patients with CHF who experience insomnia tend to have more severe depressive symptoms, cognitive frailty, and poor social support. Thus, interventions to recognize insomnia early, improve depressive symptoms, and provide social support may reduce cognitive frailty in older patients with CHF. Longitudinal studies are necessary to further refine our findings and address the limitations of the current study.
老年慢性心力衰竭(CHF)患者易患失眠症。研究表明,失眠会影响认知功能下降的发生,并且还与抑郁症状和社会支持密切相关。然而,关于这些因素如何相互作用以影响认知功能下降的信息仍未得到充分探索。
本研究的目的是探讨抑郁症状和社会支持在失眠与认知功能下降之间关系中的多重中介作用。
我们招募了300名住院的老年CHF患者参与本研究。参与者完成了雅典失眠量表、老年抑郁量表、蒙特利尔认知评估量表、FRAIL量表和社会支持评定量表。使用多重中介模型和自抽样法检验中介假设。
在本研究中,44%的患者患有失眠症,51.3%处于认知功能下降状态。我们的主要研究结果表明,失眠通过两条途径对认知功能下降产生间接影响:抑郁症状和社会支持的多重中介作用,以及抑郁症状的单一中介作用。失眠对认知功能下降的直接影响也很显著。
患有失眠症的老年CHF患者往往有更严重的抑郁症状、认知功能下降和较差的社会支持。因此,早期识别失眠、改善抑郁症状和提供社会支持的干预措施可能会降低老年CHF患者的认知功能下降。有必要进行纵向研究以进一步完善我们的研究结果并解决当前研究的局限性。