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罗哌卡因腘窝坐骨神经阻滞后足下垂:一例报告及文献综述

Foot Drop Following a Popliteal Sciatic Nerve Block with Ropivacaine, A Case Report and Literature Review.

作者信息

Clipet-Jensen Andreas, Fjeldsøe-Nielsen Hans, Roy Kirkegaard Peter

机构信息

Department of Anesthesiology and Intensive Care Medicine, Zealand University Hospital, Nykøbing, Denmark.

出版信息

Local Reg Anesth. 2024 Jul 11;17:87-91. doi: 10.2147/LRA.S470574. eCollection 2024.

DOI:10.2147/LRA.S470574
PMID:39011053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11249064/
Abstract

Although peripheral nerve blocks are deemed very safe, a significant number of patients for whom this anesthetic technique may be particularly appealing to apply may present with preexisting peripheral neuropathies, putting them at risk for further nerve damage. We present a case with a 74-year-old male with several risk factors for peripheral neuropathy who developed a foot drop following a popliteal sciatic nerve block with ropivacaine. We suggest that the vasoconstrictive properties of ropivacaine may have contributed to a preexisting neuronal ischemia, thus further damaging an already compromised nerve.

摘要

尽管周围神经阻滞被认为非常安全,但对于许多可能特别适合应用这种麻醉技术的患者来说,他们可能已有周围神经病变,这使他们面临进一步神经损伤的风险。我们报告一例74岁男性患者,该患者有多种周围神经病变的危险因素,在接受罗哌卡因腘窝坐骨神经阻滞后出现足下垂。我们认为,罗哌卡因的血管收缩特性可能导致了已存在的神经元缺血,从而进一步损害了本已受损的神经。

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本文引用的文献

1
Neurotoxic Effects of Local Anesthetics on Developing Motor Neurons in a Rat Model.局部麻醉药对大鼠模型中发育中运动神经元的神经毒性作用。
J Clin Med. 2021 Feb 25;10(5):901. doi: 10.3390/jcm10050901.
2
Comparison of peripheral nerve blockade characteristics between non-diabetic patients and patients suffering from diabetic neuropathy: a prospective cohort study.非糖尿病患者与糖尿病周围神经病变患者外周神经阻滞特征的比较:一项前瞻性队列研究。
Anaesthesia. 2018 Sep;73(9):1110-1117. doi: 10.1111/anae.14347. Epub 2018 Jun 2.
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Regional anesthesia in diabetic peripheral neuropathy.糖尿病性周围神经病变中的区域麻醉
Curr Opin Anaesthesiol. 2017 Oct;30(5):627-631. doi: 10.1097/ACO.0000000000000506.
4
Factors Associated With Risk of Neurologic Complications After Peripheral Nerve Blocks: A Systematic Review.外周神经阻滞后神经并发症风险的相关因素:一项系统评价
Anesth Analg. 2017 Feb;124(2):645-660. doi: 10.1213/ANE.0000000000001804.
5
The comparative cytotoxic effects of different local anesthetics on a human neuroblastoma cell line.不同局部麻醉剂对人神经母细胞瘤细胞系的比较细胞毒性作用。
Anesth Analg. 2015 Mar;120(3):589-596. doi: 10.1213/ANE.0000000000000562.
6
Management of the patient with diabetic peripheral neuropathy presenting for peripheral regional anesthesia: a European survey and review of literature.糖尿病周围神经病变患者行周围区域阻滞麻醉的管理:一项欧洲调查和文献回顾。
Minerva Anestesiol. 2013 Sep;79(9):1039-48. Epub 2013 May 6.
7
Vasoconstriction potency induced by aminoamide local anesthetics correlates with lipid solubility.氨基酰胺类局部麻醉药引起的血管收缩效能与脂溶性相关。
J Biomed Biotechnol. 2012;2012:170958. doi: 10.1155/2012/170958. Epub 2012 Jun 17.
8
Diabetic neuropathy: clinical manifestations and current treatments.糖尿病神经病变:临床表现与现行疗法。
Lancet Neurol. 2012 Jun;11(6):521-34. doi: 10.1016/S1474-4422(12)70065-0. Epub 2012 May 16.
9
Regional anesthesia in patients with preexisting neuropathy.已有神经病变患者的区域麻醉
Int Anesthesiol Clin. 2011 Fall;49(4):144-65. doi: 10.1097/AIA.0b013e3182101134.
10
Future considerations for pharmacologic adjuvants in single-injection peripheral nerve blocks for patients with diabetes mellitus.糖尿病患者单次外周神经阻滞中药物佐剂的未来考虑因素。
Reg Anesth Pain Med. 2009 Sep-Oct;34(5):445-57. doi: 10.1097/AAP.0b013e3181ac9e42.