Di Marco Sara, Padovan Anna M, Conti Novella, Aimasso Francesca, Viazzi Francesca, Fontana Vincenzo, Campanella Dalila, Kuvačić Goran, De Giorgio Andrea
Nephrology, Dialysis, and Transplant Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Associazione Kiara, Rome, Italy.
Front Med (Lausanne). 2024 Jul 1;11:1425921. doi: 10.3389/fmed.2024.1425921. eCollection 2024.
Chronic kidney disease (CKD) globally represents a significant health challenge, particularly among patients undergoing chronic hemodialysis. A careful nutritional and pharmacological prescription plays a key role in the effective management of these patients to optimize serum electrolytes, such as potassium, phosphorus, and protein intake. Furthermore, these patients can suffer psychological distress due to dietary restrictions and tight medication schedules. The present study explores the effectiveness of the person-centered IARA model in improving physiological markers and quality of life in CKD patients undergoing hemodialysis treatment. To demonstrate the effectiveness of the IARA model, 60 patients ( = 40; = 20; 60.5 ± 9.9 years) undergoing thrice-weekly hemodialysis sessions were enrolled and randomly and blindly assigned to the Control or IARA group. The reduction in abnormal blood potassium, phosphorus, and total protein levels was investigated, alongside the psychological state through the SF-12 questionnaire. Preliminary findings showed a discernible reduction in the frequency of abnormal blood K (> 5.0 mmol/L) and P (> 4.5 mmol/L) levels in the IARA group compared to the Control group. In particular, such reductions were approximately 40% for K (OR = 0.57; 95% CL = 0.23/1.46) and about 15% for P (OR = 0.86; 95% CL = 0.27/2.74). A similar tendency was also observed for patient fluid intake during each hemodialysis session, with the frequency of higher-risk patients in the IARA group being 50% lower (OR = 0.50; 95% CL = 0.07/3.79) than that of the Control group. Although preliminary findings from this study suggest that the IARA model may have a positive effect on CKD patients' subjective wellbeing and quality of life (QoL), further research is needed to understand the long-term impact of the IARA intervention.
慢性肾脏病(CKD)在全球范围内都是一项重大的健康挑战,尤其是在接受慢性血液透析的患者中。精心制定营养和药物处方对于有效管理这些患者、优化血清电解质(如钾、磷和蛋白质摄入量)起着关键作用。此外,这些患者可能会因饮食限制和严格的用药时间表而遭受心理困扰。本研究探讨了以患者为中心的IARA模型在改善接受血液透析治疗的CKD患者生理指标和生活质量方面的有效性。为了证明IARA模型的有效性,招募了60名每周进行三次血液透析的患者(男性 = 40名;女性 = 20名;年龄60.5 ± 9.9岁),并将他们随机、盲法分配到对照组或IARA组。研究调查了血钾、血磷和总蛋白异常水平的降低情况,同时通过SF - 12问卷评估心理状态。初步研究结果显示,与对照组相比,IARA组血液中异常血钾(> 5.0 mmol/L)和血磷(> 4.5 mmol/L)水平的出现频率明显降低。特别是,血钾水平的降低幅度约为40%(OR = 0.57;95%可信区间 = 0.23/1.46),血磷水平约为15%(OR = 0.86;95%可信区间 = 0.27/2.74)。在每次血液透析过程中患者的液体摄入量方面也观察到了类似趋势,IARA组中高风险患者的频率比对照组低50%(OR = 0.50;95%可信区间 = 0.07/3.79)。尽管本研究的初步结果表明IARA模型可能对CKD患者的主观幸福感和生活质量(QoL)有积极影响,但仍需要进一步研究以了解IARA干预的长期影响。