Ademola B L, Obiagwu P N, Aliyu A
Consultant Nephrologist, Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
Consultant Paediatric Nephrologist, Department of Paediatrics, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
Niger J Clin Pract. 2020 Jul;23(7):906-911. doi: 10.4103/njcp.njcp_589_19.
The prevalence of chronic kidney disease (CKD) is increasing globally. Recently, the concept of Health-Related Quality of Life (HRQOL) is receiving attention as a measure of treatment outcome in addition to traditional morbidity and mortality rates.
To assess the HRQOL of CKD patients stages 1-5 using the Kidney Disease Quality of Life questionnaire (KDQOL).
The study was a cross-sectional study of CKD patients at a teaching hospital in north-western Nigeria during the study period. The quality of life, sociodemographic, clinical, and laboratory variables were assessed using a pro forma and the KDQOL questionnaire during regular clinic visits/dialysis sessions. Age and sex-matched healthy volunteers without evidence of renal disease were recruited from the hospital environment into a comparison group.
A total of 150 subjects with CKD and 150 individuals in the comparison group completed the study with 77 males and 73 females for both groups. The mean ± standard deviation (SD) ages of the CKD and comparison group was 52.83 ± 14.21 and 52.43 ± 14.50 years, respectively. Subjects in the comparison group had higher physical composite summary (PCS) and mental composite summary (MCS) scores than individuals with CKD (P value < 0.05). Subjects with CKD showed a progressive decline in the scores of all HRQOL domains with advancing CKD stages (P value < 0.05).
The results suggest that subjects with CKD have worse HRQOL domain scores when compared to the normal population and these scores progressively worsened with advancing CKD stages.
慢性肾脏病（CKD）在全球的患病率正在上升。最近，健康相关生活质量（HRQOL）的概念作为除传统发病率和死亡率之外的治疗结果衡量指标正受到关注。
使用肾脏病生活质量问卷（KDQOL）评估1 - 5期CKD患者的HRQOL。
该研究是在研究期间对尼日利亚西北部一家教学医院的CKD患者进行的横断面研究。在定期门诊就诊/透析期间，使用一份表格和KDQOL问卷评估生活质量、社会人口统计学、临床和实验室变量。从医院环境中招募年龄和性别匹配且无肾脏疾病证据的健康志愿者作为对照组。
共有150名CKD受试者和150名对照组个体完成了研究，两组均有77名男性和73名女性。CKD组和对照组的平均年龄±标准差（SD）分别为52.83±14.21岁和52.43±14.50岁。对照组受试者的身体综合总结（PCS）和精神综合总结（MCS）得分高于CKD患者（P值<0.05）。随着CKD分期的推进，CKD患者在所有HRQOL领域的得分均呈逐渐下降趋势（P值<0.05）。
结果表明，与正常人群相比，CKD患者的HRQOL领域得分更差，且随着CKD分期的推进，这些得分逐渐恶化。
